The associations of gut microbiota, endocrine system and bone metabolism.
- 2023-04-06
- Frontiers in microbiology 14
- Ye Tu
- Xinyi Kuang
- Ling Zhang
- Xin Xu
- PubMed: 37089533
- DOI: 10.3389/fmicb.2023.1124945
Study Design
- Type
- Review
Gut microbiota is of great importance in human health, and its roles in the maintenance of skeletal homeostasis have long been recognized as the "gut-bone axis." Recent evidence has indicated intercorrelations between gut microbiota, endocrine system and bone metabolism. This review article discussed the complex interactions between gut microbiota and bone metabolism-related hormones, including sex steroids, insulin-like growth factors, 5-hydroxytryptamine, parathyroid hormone, glucagon-like peptides, peptide YY, etc. Although the underlying mechanisms still need further investigation, the regulatory effect of gut microbiota on bone health via interplaying with endocrine system may provide a new paradigm for the better management of musculoskeletal disorders.