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THE EFFECT OF A SINGLE ORAL DOSE OF L-ARGININE ON QUADRICEPS STRENGTH IN SMOKERS AND NON-SMOKERS: A NON-RANDOMIZED CLINICAL TRIAL.

  • 2024-10-01
  • Acta clinica Croatica 63(2)
    • Goranka Radmilović
    • Sanja Popović-Grle
    • Valentina Matijević

Study Design

Type
Clinical Trial
Sample size
n = 164
Population
164 subjects, 84 non-smokers and 81 smokers not diagnosed with COPD
Methods
All subjects completed CAT and IPAQ questionnaires, and performed spirometry, 6-minute walking test and quadriceps strength testing without therapy and after oral administration of 500 mg L-arginine
Blinding
Open-label
  • Large Human Trial
Smoking is a major risk factor for the development of chronic obstructive pulmonary disease (COPD), which is thought to be caused by smoking in even 8 out of 10 cases. One of the first clinical signs in patients with COPD is reduced physical ability, which is usually attributed to reduced lung function, although a significant role is played by a disorder of the musculoskeletal system. The aim of the study was to examine differences in fitness and locomotor status between smokers and non-smokers, as well as the effect of oral administration of L-arginine on the strength of the quadriceps depending on smoking status. The study included 164 subjects, 84 non-smokers and 81 smokers not diagnosed with COPD. All subjects completed CAT and IPAQ questionnaires, and performed spirometry, 6-minute walking test and quadriceps strength testing without therapy and after oral administration of 500 mg L-arginine. The results showed that the increase in quadriceps strength after oral administration of L-arginine was not dependent on smoking status but was more pronounced in smokers who started smoking at an earlier age and who smoked more cigarettes, as well as a generally higher physical activity of non-smokers. These results could become relevant for recognizing the development of skeletal musculature hypotonus and hypotrophy in smokers who are prone to develop COPD.

Research Insights

  • L-Arginine→Improved Quadriceps Strength

    the increase in quadriceps strength after oral administration of L-arginine was not dependent on smoking status but was more pronounced in smokers who started smoking at an earlier age and who smoked more cigarettes

    Effect
    Beneficial
    Effect size
    Small
    Dose
    500 mg (single oral dose)
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