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The effect of Cuminum cyminum on the return of bowel motility after abdominal surgery: a triple-blind randomized clinical trial.

  • 2024-07-04
  • BMC complementary medicine and therapies 24(1)
    • Esmaeili Abdar Amin
    • Elahabadi Ismail
    • Raeiszadeh Mahboobeh
    • Sadeghi Tabandeh

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 74
Population
74 patients undergoing abdominal surgery
Methods
Triple-blind clinical trial, 74 patients assigned by minimization, intervention: 250 mg Cuminum cyminum extract capsules at 4h and 1h post-surgery, control: placebo starch capsules
Blinding
Triple-blind
Funding
Unclear

Background and objectives

Considering the significant prevalence of ileus after abdominal surgery and the beneficial effects of Cuminum cyminum in digestive problems, this study aimed to examine whether Cuminum cyminum has any effect on the return of bowel motility after abdominal surgery.

Materials and methods

In this triple-blind clinical trial study, 74 patients undergoing abdominal surgery were assigned to the intervention and control groups using minimization methods. The patients in the intervention group consumed 250 mg capsules containing Cuminum cyminum extract 4 h after the surgery and another dose of the drug 1 h afterward. The patients in the control group consumed a 250 mg capsule containing starch as a placebo at hours similar to those in the intervention group. The instruments used to collect the data were a demographic questionnaire and a researcher-made checklist to assess bowel habits. The data were analyzed using SPSS-22 software.

Results

The average time of gas passing in the intervention and control groups was 9.03 ± 3.41 and 11.72 ± 4.21 h, respectively. The defecation times in the intervention and control groups were 16.97 ± 5.02 and 26 ± 9.87 h, showing a significant difference between the two groups as indicated by the independent samples T-test (P > 0.001). Furthermore, abdominal pain, abdominal bloating, nausea, and vomiting were significantly less frequent in the intervention group compared to the control group as confirmed by Fisher's exact test (P > 0.001).

Conclusion

According to the results, the consumption of Cuminum cyminum after abdominal surgery helps to reduce the time of gas passing, defecation, and the return of bowel motility. However, additional studies need to address the effectiveness of Cuminum cyminum by changing the time and duration of its use.

Research Insights

  • Cumin→Reduced Abdominal Pain

    abdominal pain, abdominal bloating, nausea, and vomiting were significantly less frequent in the intervention group compared to the control group as confirmed by Fisher's exact test (P > 0.001).

    Effect
    Beneficial
    Effect size
    Small
    Dose
    250 mg capsules containing Cuminum cyminum extract at 4 h and 1 h after surgery
  • Cumin→Reduced Bloating

    abdominal pain, abdominal bloating, nausea, and vomiting were significantly less frequent in the intervention group compared to the control group as confirmed by Fisher's exact test (P > 0.001).

    Effect
    Beneficial
    Effect size
    Small
    Dose
    250 mg capsules containing Cuminum cyminum extract at 4 h and 1 h after surgery
  • Cumin→Reduced Flatulence

    The average time of gas passing in the intervention and control groups was 9.03 ± 3.41 and 11.72 ± 4.21 h, respectively.

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    250 mg capsules containing Cuminum cyminum extract at 4 h and 1 h after surgery
  • Cumin→Reduced Nausea

    abdominal pain, abdominal bloating, nausea, and vomiting were significantly less frequent in the intervention group compared to the control group as confirmed by Fisher's exact test (P > 0.001).

    Effect
    Beneficial
    Effect size
    Small
    Dose
    250 mg capsules containing Cuminum cyminum extract at 4 h and 1 h after surgery
  • Cumin→Reduced Time to First Defecation

    The defecation times in the intervention and control groups were 16.97 ± 5.02 and 26 ± 9.87 h, showing a significant difference between the two groups as indicated by the independent samples T-test (P > 0.001).

    Effect
    Beneficial
    Effect size
    Large
    Dose
    250 mg capsules containing Cuminum cyminum extract at 4 h and 1 h after surgery
  • Cumin→Reduced Vomiting

    abdominal pain, abdominal bloating, nausea, and vomiting were significantly less frequent in the intervention group compared to the control group as confirmed by Fisher's exact test (P > 0.001).

    Effect
    Beneficial
    Effect size
    Small
    Dose
    250 mg capsules containing Cuminum cyminum extract at 4 h and 1 h after surgery
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