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The effect of Eurycoma Longifolia on the regulation of reproductive hormones in young males.

  • 2021-02-09
  • Andrologia 53(4)
    • Kai Quin Chan
    • Claire Stewart
    • Neil Chester
    • Sareena H Hamzah
    • Ashril Yusof

Study Design

Type
Randomized Controlled Trial (RCT)
Population
32 healthy young males (24.4 ± 4.7 years; 1.74 ± 0.07 m; 73.7 ± 8.4 kg)
Methods
placebo-controlled, double-blind, matched-paired study received 600 mg/day Eurycoma longifolia or placebo for two weeks
Blinding
Double-blind
Duration
two weeks
Funding
Unclear
Eurycoma longifolia supplementation increases testosterone levels in humans via activation of the hypothalamic-pituitary-gonadal axis and/or the hypothalamic-pituitary-adrenal axis mainly in older adults and nonhealthy populations. This study aimed to assess the impact of Eurycoma longifolia on the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes in healthy young males since this might promote functional testosterone prowess. Thirty-two males (24.4 ± 4.7 years; 1.74 ± 0.07 m; 73.7 ± 8.4 kg) in a placebo-controlled, double-blind, matched-paired study received 600 mg/day Eurycoma longifolia or placebo for two weeks. Blood analysis using repeated measures analysis of variance showed significant interaction and time effects for testosterone (F1,30  = 9.04, p = .005), free testosterone (F1,30  = 7.13, p = .012) and estradiol (F1,30  = 8.07, p = .008) levels in favour of the treatment group, while luteinising hormone, follicle-stimulating hormone and sexual hormone-binding globulin did not. The lack of changes in luteinising hormone and follicle-stimulating hormone levels suggests that a lesser role played by Eurycoma longifolia in activating the hypothalamic-pituitary-gonadal axis in the young adults. The raised testosterone level may be due to a greater rate of hormone production via the hypothalamic-pituitary-adrenal axis. The supplementation of Eurycoma longifolia for two weeks demonstrates steroidogenic effects on young men were dose-related. Consequently, the raised testosterone following Eurycoma longifolia supplementations could benefit muscle and strength gain in young adults.

Research Insights

  • Eurycoma→Increased Estradiol Level

    Blood analysis...showed significant interaction and time effects for...estradiol (F1,30 = 8.07, p = .008)...in favour of the treatment group

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    600 mg/day
  • Eurycoma→Increased Follicle-Stimulating Hormone Level

    luteinising hormone, follicle-stimulating hormone and sexual hormone-binding globulin did not [show significant effects]

    Effect
    Neutral
    Effect size
    Small
    Dose
    600 mg/day
  • Eurycoma→Increased Luteinizing Hormone Level

    luteinising hormone, follicle-stimulating hormone and sexual hormone-binding globulin did not [show significant effects]

    Effect
    Neutral
    Effect size
    Small
    Dose
    600 mg/day
  • Eurycoma→Increased Sex Hormone-Binding Globulin Level

    luteinising hormone, follicle-stimulating hormone and sexual hormone-binding globulin did not [show significant effects]

    Effect
    Neutral
    Effect size
    Small
    Dose
    600 mg/day
  • Eurycoma→Increased Testosterone Level

    Blood analysis...showed significant interaction and time effects for testosterone (F1,30 = 9.04, p = .005)...in favour of the treatment group

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    600 mg/day
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