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The effect of N-acetyl cysteine on the volume of uterine leiomyoma: A randomized clinical trial.

  • 2021-02-23
  • International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 154(3)
    • Shahrzad Aghaamoo
    • Azade Zandbina
    • Elham Saffarieh
    • Setare Nassiri

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 25
Population
50 women with uterine leiomyoma
Methods
Randomized clinical trial, women randomly assigned to receive NAC or placebo for 12 weeks
Duration
12 weeks
Funding
Unclear

Objective

To conduct a clinical trial to investigate the effect of N-acetyl cysteine (NAC), a non-hormonal drug, on the volume of leiomyoma, the most common benign tumor in women.

Methods

This study is a randomized clinical trial, which was performed in Semnan, Iran. Eligible women who were diagnosed with uterine leiomyoma using vaginal ultrasound were randomly assigned to receive NAC or placebo for 12 weeks. The change in the volume of Leiomyoma was considered to be the main variable in the efficacy evaluation. Reduction in the leiomyoma volume was calculated after intervention and data were entered in SPSS version 23.

Results

Fifty individuals were enrolled in our study. 25 women received NAC, while 25 women took placebo. The mean volume of leiomyoma in group A was 5.71 cm3 and in group B was 6.56 cm3 . The mean rate of volume reduction in the A and B groups was 25.25 % and 1.08 %, respectively, which demonstrated a significant difference between the two groups (P < 0.004).

Conclusion

Although this trial recommends the use of NAC as a non-hormonal drug in the treatment of leiomyoma of the uterus, the possibility of treatment failure in controlling abnormal uterine bleeding cannot be ignored. Nevertheless, we can say it is feasible and effective in the reduction of leiomyoma volume.

Research Insights

  • N-Acetyl Cysteine→Reduced Leiomyoma Volume

    The mean rate of volume reduction in the A and B groups was 25.25 % and 1.08 %, respectively, which demonstrated a significant difference between the two groups (P < 0.004).

    Effect
    Beneficial
    Effect size
    Moderate
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