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The effect of probiotic Bifidobacterium lactis Bl-04 on innate antiviral responses invitro.

  • 2024-04
  • Heliyon 10(8)
    • Sinikka Latvala
    • Markus J Lehtinen
    • Sanna M Mäkelä
    • Derek Nedveck
    • Bryan Zabel
    • Ilmari Ahonen
    • Liisa Lehtoranta
    • Ronald B Turner
    • Jenni Liljavirta

Study Design

Population
human monocyte-derived macrophages and dendritic cells, and MRC-5 fibroblasts
Methods
We investigated the effect of Bifidobacterium lactis Bl-04 on cytokine production and transcriptomes of human monocyte-derived macrophages and dendritic cells, and further on RV replication and cytokine production in MRC-5 fibroblasts.
Consumption of certain probiotic strains may be beneficial for reducing the risk of acute upper respiratory tract infections (URTIs), however, underlying immunological mechanisms are elusive. Bifidobacterium lactis Bl-04™ has been reported in humans to significantly reduce the risk of URTIs, affect the innate immunity in the nasal mucosa, and reduce nasal lavage virus titer after a rhinovirus (RV) challenge. To study the immunological mechanisms, we investigated the effect of Bl-04 on cytokine production and transcriptomes of human monocyte-derived macrophages (Mfs) and dendritic cells (DCs), and further on RV replication and cytokine production in MRC-5 fibroblasts. The results showed that Bl-04 modulates antiviral immune responses and potentiates cytokine production during viral challenge mimic in immune cells. However, effect of Bl-04 on RV replication and cytokine production in fibroblasts was negligible. Overall, the findings suggest that Bl-04 mildly stimulates antiviral immunity in Mfs and DCs, and potentially influences viral replication in fibroblasts that however warrants further investigations.

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