The effect of probiotic Bifidobacterium lactis Bl-04 on innate antiviral responses invitro.
- 2024-04
- Heliyon 10(8)
- PubMed: 38665561
- DOI: 10.1016/j.heliyon.2024.e29588
Study Design
- Population
- human monocyte-derived macrophages and dendritic cells, and MRC-5 fibroblasts
- Methods
- We investigated the effect of Bifidobacterium lactis Bl-04 on cytokine production and transcriptomes of human monocyte-derived macrophages and dendritic cells, and further on RV replication and cytokine production in MRC-5 fibroblasts.
Consumption of certain probiotic strains may be beneficial for reducing the risk of acute upper respiratory tract infections (URTIs), however, underlying immunological mechanisms are elusive. Bifidobacterium lactis Bl-04™ has been reported in humans to significantly reduce the risk of URTIs, affect the innate immunity in the nasal mucosa, and reduce nasal lavage virus titer after a rhinovirus (RV) challenge. To study the immunological mechanisms, we investigated the effect of Bl-04 on cytokine production and transcriptomes of human monocyte-derived macrophages (Mfs) and dendritic cells (DCs), and further on RV replication and cytokine production in MRC-5 fibroblasts. The results showed that Bl-04 modulates antiviral immune responses and potentiates cytokine production during viral challenge mimic in immune cells. However, effect of Bl-04 on RV replication and cytokine production in fibroblasts was negligible. Overall, the findings suggest that Bl-04 mildly stimulates antiviral immunity in Mfs and DCs, and potentially influences viral replication in fibroblasts that however warrants further investigations.
Research Insights
| Supplement | Dose | Health Outcome | Effect Type | Effect Size | Source |
|---|---|---|---|---|---|
| Bifidobacterium lactis | — | Enhanced Innate Antiviral Immune Response | Beneficial | Small | View sourceBl-04 mildly stimulates antiviral immunity in Mfs and DCs |
| Bifidobacterium lactis | — | Reduced Rhinovirus Nasal Lavage Titer | Beneficial | Small | View sourcereduce nasal lavage virus titer after a rhinovirus (RV) challenge |
| Bifidobacterium lactis | — | Reduced Risk of Upper Respiratory Tract Infections | Beneficial | Moderate | View sourceBifidobacterium lactis Bl-04™ has been reported in humans to significantly reduce the risk of URTIs |