The effect of propolis plus Hyoscyamus niger L. methanolic extract on clinical symptoms in patients with acute respiratory syndrome suspected to COVID-19: A clinical trial.

2021-04-15
Phytotherapy research : PTR 35(7)
- Morteza Kosari
- Mehdi Noureddini
- Seyed Peyman Khamechi
- Ahmad Najafi
- Amir Ghaderi
- Mojtaba Sehat
- Hamid Reza Banafshe

PubMed: 33860587
DOI: 10.1002/ptr.7116

Study Design

Type: Randomized Controlled Trial (RCT)
Population: 50 patients with COVID-19
Methods: Randomized clinical trial; syrup containing 1.6 mg of methanolic extract along with 450 mg of propolis per 10 mL administered three times a day for 6 days
Duration: 6 days
Funding: Unclear

The outbreak of Coronavirus disease 2019 (COVID-19) has caused a global health crisis. Nevertheless, no antiviral treatment has yet been proven effective for treating COVID-19 and symptomatic supportive cares have been the most common treatment. Therefore, the present study was designed to evaluate the effects of propolis and Hyoscyamus niger L. extract in patients with COVID-19. This randomized clinical trial was conducted on 50 cases referred to Akhavan and Sepehri Clinics, Kashan university of medical sciences, Iran. Subjects were divided into two groups (intervention and placebo). This syrup (containing 1.6 mg of methanolic extract along with 450 mg of propolis per 10 mL) was administered three times a day to each patient for 6 days. The clinical symptoms of COVID-19 such as: dry cough, shortness of breath, sore throat, chest pain, fever, dizziness, headache, abdominal pain, and diarrhea were reduced with propolis plus Hyoscyamus niger L. extract than the placebo group. However, the administration of syrup was not effective in the control of nausea and vomiting. In conclusion, syrup containing propolis and Hyoscyamus niger L. extract had beneficial effects in ameliorating the signs and symptoms of COVID-19 disease, in comparison with placebo groups.

Research Insights

Propolis→Reduced Abdominal Pain
The clinical symptoms of COVID-19 such as: dry cough, shortness of breath, sore throat, chest pain, fever, dizziness, headache, abdominal pain, and diarrhea were reduced with propolis plus Hyoscyamus niger L. extract than the placebo group.
Effect
Beneficial
Effect size
Small
Dose
450 mg three times daily
Propolis→Reduced Chest Pain
The clinical symptoms of COVID-19 such as: dry cough, shortness of breath, sore throat, chest pain, fever, dizziness, headache, abdominal pain, and diarrhea were reduced with propolis plus Hyoscyamus niger L. extract than the placebo group.
Effect
Beneficial
Effect size
Small
Dose
450 mg three times daily
Propolis→Reduced Diarrhea
The clinical symptoms of COVID-19 such as: dry cough, shortness of breath, sore throat, chest pain, fever, dizziness, headache, abdominal pain, and diarrhea were reduced with propolis plus Hyoscyamus niger L. extract than the placebo group.
Effect
Beneficial
Effect size
Small
Dose
450 mg three times daily
Propolis→Reduced Dizziness
The clinical symptoms of COVID-19 such as: dry cough, shortness of breath, sore throat, chest pain, fever, dizziness, headache, abdominal pain, and diarrhea were reduced with propolis plus Hyoscyamus niger L. extract than the placebo group.
Effect
Beneficial
Effect size
Small
Dose
450 mg three times daily
Propolis→Reduced Dry Cough
The clinical symptoms of COVID-19 such as: dry cough, shortness of breath, sore throat, chest pain, fever, dizziness, headache, abdominal pain, and diarrhea were reduced with propolis plus Hyoscyamus niger L. extract than the placebo group.
Effect
Beneficial
Effect size
Small
Dose
450 mg three times daily
Propolis→Reduced Fever
The clinical symptoms of COVID-19 such as: dry cough, shortness of breath, sore throat, chest pain, fever, dizziness, headache, abdominal pain, and diarrhea were reduced with propolis plus Hyoscyamus niger L. extract than the placebo group.
Effect
Beneficial
Effect size
Small
Dose
450 mg three times daily
Propolis→Reduced Headache
The clinical symptoms of COVID-19 such as: dry cough, shortness of breath, sore throat, chest pain, fever, dizziness, headache, abdominal pain, and diarrhea were reduced with propolis plus Hyoscyamus niger L. extract than the placebo group.
Effect
Beneficial
Effect size
Small
Dose
450 mg three times daily
Propolis→Reduced Shortness of Breath
The clinical symptoms of COVID-19 such as: dry cough, shortness of breath, sore throat, chest pain, fever, dizziness, headache, abdominal pain, and diarrhea were reduced with propolis plus Hyoscyamus niger L. extract than the placebo group.
Effect
Beneficial
Effect size
Small
Dose
450 mg three times daily
Propolis→Reduced Sore Throat
The clinical symptoms of COVID-19 such as: dry cough, shortness of breath, sore throat, chest pain, fever, dizziness, headache, abdominal pain, and diarrhea were reduced with propolis plus Hyoscyamus niger L. extract than the placebo group.
Effect
Beneficial
Effect size
Small
Dose
450 mg three times daily
Propolis→Reduced Vomiting Frequency
However, the administration of syrup was not effective in the control of nausea and vomiting.
Effect
Neutral
Effect size
Small
Dose
450 mg three times daily