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The effect of Rosa (L. Rosa canina) on the incidence of urinary tract infection in the puerperium: A randomized placebo-controlled trial.

  • 2017-10-11
  • Phytotherapy research : PTR 32(1)
    • Mahdieh Seifi
    • Shamsi Abbasalizadeh
    • Sakineh Mohammad-Alizadeh-Charandabi
    • Laleh Khodaie
    • Mojgan Mirghafourvand

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 400
Population
400 women following cesarean section with negative urine culture
Methods
Triple-blind randomized clinical trial, 500 mg capsules of R. canina or placebo twice daily for 20 days from the second day after cesarean section
Blinding
Triple-blind
Duration
20 days
Funding
Unclear
  • Large Human Trial
Urinary tract infection (UTI) is an infection that can occur in any area of the urinary tract which is characterized by a positive urine culture (U/C). The risk of UTI following cesarean section (CS) increases due to procedures such as catheterization. In vitro studies have demonstrated the effect of Rosa canina fruit in preventing Escherichia coli growth. This study was conducted to determine the effect of R. canina fruit in preventing the incidence of UTI in women following CS. This triple-blind randomized clinical trial was conducted in 2016 on 400 women following CS with negative U/C in Alzahra and Taleghani educational hospitals in the city of Tabriz-Iran. Participants were assigned into two groups of 200 women using block randomization. Each group received a twice daily dose of 500 mg capsules containing R. canina or placebo from the second day after CS for 20 days. Women were assessed by U/C on the 7th-10th and 20th days following CS. UTI was significantly lower in the intervention group compared with the control in the follow-ups conducted on the 7th-10th days (odds ratio = 0.22; confidence interval 95% [0.07, 0.67]; p = .006) and 20th day (odds ratio = 0.32; confidence interval 95% [0.14, 0.75]; p = .008). But the incidence of cystitis in the two groups was not statistically significant (p > .05). R. canina fruit capsules were able to reduce the incidence of UTI after CS. Thus, it is likely that administration of this medication can promote maternal health following CS.

Research Insights

  • Rose Hip→Reduced Cystitis Incidence

    But the incidence of cystitis in the two groups was not statistically significant (p > .05).

    Effect
    Neutral
    Effect size
    Small
    Dose
    500 mg capsules twice daily
  • Rose Hip→Reduced Urinary Tract Infection

    UTI was significantly lower in the intervention group compared with the control in the follow-ups conducted on the 7th-10th days (odds ratio = 0.22; confidence interval 95% [0.07, 0.67]; p = .006) and 20th day (odds ratio = 0.32; confidence interval 95% [0.14, 0.75]; p = .008).

    Effect
    Beneficial
    Effect size
    Large
    Dose
    500 mg capsules twice daily
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