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The effects of adjunctive treatment with L-carnitine on monitoring laboratory variables in ICU patients: a double-blinded randomized controlled clinical trial.

  • 2023-01-03
  • Trials 24(1)
    • Farveh Yahyapoor
    • Mahdi Keshani
    • Alireza Sedaghat
    • Awat Feizi
    • Cain C T Clark
    • Mohammad Bagherniya
    • Mohammad Safarian
    • Mohaddeseh Badpeyma
    • Abdolreza Norouzy

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 54
Population
54 patients, aged > 18 years, with multiple conditions, in a medical ICU
Methods
prospective, double-blind, randomized controlled trial, 3 g L-carnitine per day or placebo, along with enteral feeding, for 1 week
Blinding
Double-blind
Duration
1 week
Funding
Unclear

Background

Critically ill patients must be monitored constantly in intensive care units (ICUs). Among many laboratory variables, nutritional status indicators are a key role in the prognosis of diseases. We investigated the effects of L-carnitine adjunctive therapy on monitoring variables in critical illness.

Method

A prospective, double-blind, randomized controlled trial was implemented in a medical ICU. Participants were 54 patients, aged > 18 years, with multiple conditions, randomly assigned to receive 3 g L-carnitine per day or placebo, along with enteral feeding, for 1 week. Primary outcomes included monitoring variables related to nutritional status.

Result

Of 54 patients randomly assigned, 51 completed the trial. Serum albumin (Alb) (P-value: 0.001), total protein (P-value: 0.003), and calcium (Ca) (0.044) significantly increased in the intervention vs. control group. Alanine transaminase (ALT) (0.022), lactate (<0.001), creatinine (Cr) (0.005), and international normalized ratio (INR) (0.049) decreased meaningfully in the intervention vs. control group.

Conclusion

L-Carnitine supplementation in critically ill patients can improve several parameters including INR, Cr, ALT, lactate, Ca, Alb, and total protein.

Trial registration

Iranian Registry of Clinical Trials IRCT 20151108024938N2. This trial was approved by the Research Ethics Committee of Mashhad University of Medical Sciences (registration code: IR.MUMS.fm.REC.1396.671) (available at https://en.irct.ir/trial/30748 , May 2018).

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