The effects of Capsicum annuum supplementation on lipid profiles in adults with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials.

2023-06-21
Phytotherapy research : PTR 37(9)
- Ahmed Hjazi
- Ahmed Hjazi
- Ahmed Hjazi

PubMed: 37344950
DOI: 10.1002/ptr.7922

Study Design

Type: Meta-Analysis
Population: adults with metabolic syndrome (MetS) and related disorders
Methods: Meta-analysis of randomized controlled trials (RCTs) studying administration of C. annuum compared to control on lipid markers

The electiveness of Capsicum annuum supplementation in controlling dyslipidemia in adults has been unclear. Therefore, this meta-analysis focuses on the relationship between C. annuum supplementation and lipid profile in adults with metabolic syndrome (MetS) and related disorders. PubMed, Scopus, ISI Web of Science, and the Cochrane Library were searched up to March 2021. Only randomized controlled trials (RCTs) studying the administration of C. annuum compared to control on lipid markers in adults with MetS and related disorders were examined. Pooled effect sizes were reported as weighted mean differences (WMDs) and 95% confidence intervals (CIs). The results of four eligible RCTs showed that C. annuum supplementation could significantly reduce total cholesterol (TC) (WMD: -4.98 mg/dL, 95% CI: -7.08 to -2.88, p ≤ 0.001) levels, but did not regulate triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol concentrations. In summary, the present findings suggest the beneficial effects of C. annuum supplementation on the reduction of plasma levels of TC. However, to draw a firm link between C. annuum supplementation and lipid profile, more trials with adequate sample sizes, specifically in subjects with dyslipidemia are warranted.

Research Insights

Chili→Increased HDL Cholesterol Levels
C. annuum supplementation could significantly reduce total cholesterol … but did not regulate triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol concentrations.
Effect
Neutral
Effect size
Small
Chili→Reduced Low-Density Lipoprotein Level
C. annuum supplementation could significantly reduce total cholesterol … but did not regulate triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol concentrations.
Effect
Neutral
Effect size
Small
Chili→Reduced Total Cholesterol
the results of four eligible RCTs showed that C. annuum supplementation could significantly reduce total cholesterol (TC) (WMD: −4.98 mg/dL, 95% CI: −7.08 to −2.88, p ≤ 0.001) levels
Effect
Beneficial
Effect size
Small
Chili→Reduced Triglyceride Levels
C. annuum supplementation could significantly reduce total cholesterol … but did not regulate triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol concentrations.
Effect
Neutral
Effect size
Small