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Abstract

(1) Background: Lactococcus lactis strain Plasma (LC-Plasma) is a unique strain which directly activates plasmacytoid dendritic cells, resulting in the prevention against broad spectrum of viral infection. Additionally, we found that LC-Plasma intake stimulated skin immunity and prevents Staphylococcus aureus epicutaneous infection. The aim of this study was to investigate the effect of LC-Plasma dietary supplementation on skin microbiome, gene expression in the skin, and skin conditions in healthy subjects. (2) Method: A randomized, double-blind, placebo-controlled, parallel-group trial was conducted. Seventy healthy volunteers were enrolled and assigned into two groups receiving either placebo or LC-Plasma capsules (approximately 1 × 1011 cells/day) for 8 weeks. The skin microbiome was analyzed by NGS and qPCR. Gene expression was analyzed by qPCR and skin conditions were diagnosed by dermatologists before and after intervention. (3) Result: LC-Plasma supplementation prevented the decrease of Staphylococcus epidermidis and Staphylococcus pasteuri and overgrowth of Propionibacterium acnes. In addition, LC-Plasma supplementation suggested to increase the expression of antimicrobial peptide genes but not tight junction genes. Furthermore, the clinical scores of skin conditions were ameliorated by LC-Plasma supplementation. (4) Conclusions: Our findings provided the insights that the dietary supplementation of LC-Plasma might have stabilizing effects on seasonal change of skin microbiome and skin conditions in healthy subjects.

Keywords: LC-Plasma; P. acnes; S. epidermidis; paraprobiotics; skin microbiome.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactococcus lactis L1A-23Improved Skin ConditionBeneficial
Moderate
Lactococcus lactis L1A-23Increased Expression of Antimicrobial Peptide GenesBeneficial
Small
Lactococcus lactis L1A-23Stabilized Skin MicrobiomeBeneficial
Moderate
Lactococcus lactis UALl-08Improved Skin ConditionBeneficial
Moderate
Lactococcus lactis UALl-08Improved Skin ImmunityBeneficial
Moderate
Lactococcus lactis UALl-08Increased Expression of Antimicrobial Peptide GenesBeneficial
Small
Lactococcus lactis UALl-08Stabilized Skin MicrobiomeBeneficial
Moderate
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