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The Effects of Pomegranate Seed Oil on Mild Cognitive Impairment.

  • 2024-01-02
  • Journal of Alzheimer's disease : JAD 97(4)
    • Thanos Chatzikostopoulos
    • Moses Gialaouzidis
    • Anna Koutoupa
    • Magda Tsolaki

Study Design

Type
Randomized Controlled Trial (RCT)
Population
Eighty people with the diagnosis of mild cognitive impairment (MCI)
Methods
randomized forty to take 5 drops of PSO and follow the Mediterranean Diet (MeDi) and forty just followed MeDi; neuropsychological assessment before and after one year
Blinding
Open-label
Duration
one year
Funding
Unclear

Background

In recent years, there has been a growing interest, supported by many experimental and clinical studies, about the benefits of pomegranate in preventing various pathologic conditions, including brain neurodegeneration. The pomegranate seed oil (PSO) contains high levels of fatty acids that have antioxidant and anti-inflammatory properties.

Objective

Due to the lack of clinical trials, the aim of the present study was to investigate the effects of PSO on cognition of people with mild cognitive impairment (MCI).

Methods

Eighty people with the diagnosis of MCI were randomized forty to take 5 drops of PSO and follow the Mediterranean Diet (MeDi) and forty just followed MeDi. All were examined with an extensive neuropsychological assessment before and after one year of treatment.

Results

The results showed that the participants who took the PSO had statistically significantly better global cognition (p = 0.004), verbal episodic memory (p = 0.009), and processing and executive functions (p < 0.001) in contrast with the participants who did not take it.

Conclusions

In conclusion, the PSO can be beneficial for people with MCI as it is helpful for some important cognitive domains. As PSO is a natural product that does not burden the human body, it can be used by people with MCI and be a significant and promising part of holistic approaches for the prevention of dementia.

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