Skip to main content
Evidence-Based Supplement Research
Evidence-Based Supplement Research
Pillser
Search
Sign UpLog In

The effects of probiotic supplements on oxidative stress and inflammation in subjects with mild and moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled study.

  • 2024-02-06
  • Inflammopharmacology 32(2)
    • Camellia Akhgarjand
    • Zahra Vahabi
    • Sakineh Shab-Bidar
    • Aliarash Anoushirvani
    • Kurosh Djafarian

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 90
Population
90 patients with mild and moderate AD
Methods
placebo-controlled, double-blind, randomized clinical trial; two different single-strain probiotics (Lacticaseibacillus rhamnosus HA-114 7.5×10^9 or Bifidobacterium longum R0175 7.5×10^9) and a placebo group, supplemented twice daily
Blinding
Double-blind
Duration
12 weeks
Through modulating effects on the gut-brain axis, probiotics are an effective adjuvant treatment for Alzheimer's disease (AD), one of our century's most important medical care challenges (Agahi et al. Front Neurol 9:662, 2018). This trial aimed to examine the effects of two different single-strain probiotics on oxidative stress and inflammation in patients with mild and moderate AD. This was a 12-week placebo-controlled, double-blind, randomized clinical trial performed on 90 patients with AD. Eligible patients were randomly assigned to two different interventions (Lacticaseibacillus rhamnosus HA-114 (7.5 × 109) or Bifidobacterium longum R0175 (7.5 × 109)) and a placebo group, supplemented twice daily. We used mixed-effect models to examine the probiotic's independent effects on clinical results. Significant improvements in serum inflammatory and oxidative stress markers were observed at the end of the trial (P < 0.05). Probiotic supplementation for 12 weeks had beneficial effects on oxidative stress, inflammation, quality of life, and physical activity in patients with mild and moderate AD.

Research Insights

  • Bifidobacterium longum R0175→Improved Physical Activity Level

    Probiotic supplementation for 12 weeks had beneficial effects on oxidative stress, inflammation, quality of life, and physical activity in patients with mild and moderate AD.

    Effect
    Beneficial
    Effect size
    Small
    Dose
    7.5×10^9 CFU twice daily
  • Bifidobacterium longum R0175→Improved Quality of Life

    Probiotic supplementation for 12 weeks had beneficial effects on oxidative stress, inflammation, quality of life, and physical activity in patients with mild and moderate AD.

    Effect
    Beneficial
    Effect size
    Small
    Dose
    7.5×10^9 CFU twice daily
  • Bifidobacterium longum R0175→Reduced Inflammation

    Probiotic supplementation for 12 weeks had beneficial effects on oxidative stress, inflammation, quality of life, and physical activity in patients with mild and moderate AD.

    Effect
    Beneficial
    Effect size
    Small
    Dose
    7.5×10^9 CFU twice daily
  • Bifidobacterium longum R0175→Reduced Oxidative Stress

    Probiotic supplementation for 12 weeks had beneficial effects on oxidative stress, inflammation, quality of life, and physical activity in patients with mild and moderate AD.

    Effect
    Beneficial
    Effect size
    Small
    Dose
    7.5×10^9 CFU twice daily
  • Lactobacillus rhamnosus HA-114→Improved Physical Activity Level

    Probiotic supplementation for 12 weeks had beneficial effects on oxidative stress, inflammation, quality of life, and physical activity in patients with mild and moderate AD.

    Effect
    Beneficial
    Effect size
    Small
    Dose
    7.5×10^9 CFU twice daily
  • Lactobacillus rhamnosus HA-114→Improved Quality of Life

    Probiotic supplementation for 12 weeks had beneficial effects on oxidative stress, inflammation, quality of life, and physical activity in patients with mild and moderate AD.

    Effect
    Beneficial
    Effect size
    Small
    Dose
    7.5×10^9 CFU twice daily
  • Lactobacillus rhamnosus HA-114→Reduced Inflammation

    Probiotic supplementation for 12 weeks had beneficial effects on oxidative stress, inflammation, quality of life, and physical activity in patients with mild and moderate AD.

    Effect
    Beneficial
    Effect size
    Small
    Dose
    7.5×10^9 CFU twice daily
  • Lactobacillus rhamnosus HA-114→Reduced Oxidative Stress

    Probiotic supplementation for 12 weeks had beneficial effects on oxidative stress, inflammation, quality of life, and physical activity in patients with mild and moderate AD.

    Effect
    Beneficial
    Effect size
    Small
    Dose
    7.5×10^9 CFU twice daily
Back to top