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The effects of purslane consumption on glycemic control and oxidative stress: A systematic review and dose-response meta-analysis.

  • 2023-03-15
  • Food science & nutrition 11(6)
    • Naser Jafari
    • Nargeskhatoon Shoaibinobarian
    • Azadeh Dehghani
    • Amirhosein Rad
    • Seyedeh Nooshan Mirmohammadali
    • Mohammad Javad Alaeian
    • Yasaman Hamedi
    • Mohamad Zamani
    • Mohammad Ali Goudarzi
    • Omid Asbaghi

Study Design

Type
Review
Sample size
n = 1,122
Population
1122 participants with Type 2 Diabetes Mellitus (557 cases and 565 controls) from 16 RCTs
Methods
Systematic review and meta-analysis of 16 randomized clinical trials, using random-effects modeling
Purslane (Portulaca oleracea L.) is a herbal remedy with wide range of pharmaceutic properties. Although the beneficial effect of purslane on the treatment of Type 2 Diabetes Mellitus (T2DM) has been shown, there is an inconsistency among the results of previous studies. Therefore, this study is aimed at conducting a systematic review and meta-analysis on the effect of purslane on glycemic profile and oxidative stress markers. A systematic search was performed in the Scopus, Web of science, PubMed and the Cochrane Library to find articles related to the effect of the purslane on Malondialdehyde (MDA) and Total Antioxidant Capacity (TAC), Fasting Blood Sugar (FBS), Hemoglobin A1c (HbA1c), insulin resistance, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) up to September 2022. Among the 611 initial studies that were identified from searching electronic databases, 16 Randomized Clinical Trials (RCTs) involving 1122 participants (557 cases and 565 controls) were included for data analysis. The results of random-effects modeling demonstrated that purslane consumption significantly reduced FBS (p < .001), MDA (p < .001) and increased TAC (p < .001). However, purslane consumption did not affect HbA1c (p < .109), fasting insulin (p = .298) and HOMA-IR (p = .382). Meta-analyses were performed using both the random- and fixed-effects model where appropriate, and I2 index was used to evaluate the heterogeneity. This meta-analysis study suggests that purslane has beneficial effects on oxidative stress markers and glycemic parameter. Therefore, it may be a promising adjuvant therapy in T2DM because of its benefits and negligible adverse effects.

Research Insights

Adverse Events Reported

  • Portulaca→Overall tolerability

    Therefore, it may be a promising adjuvant therapy in T2DM because of its benefits and negligible adverse effects.

    Finding
    Reported
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