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The effects of rutin flavonoid supplement on glycemic status, lipid profile, atherogenic index of plasma, brain-derived neurotrophic factor (BDNF), some serum inflammatory, and oxidative stress factors in patients with type 2 diabetes mellitus: A double-blind, placebo-controlled trial.

  • 2022-09-13
  • Phytotherapy research : PTR 37(1)
    • Hadi Bazyar
    • Leila Moradi
    • Ferdows Zaman
    • Ahmad Zare Javid

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 25
Population
50 T2DM patients (supplement, n = 25 and placebo, n = 25)
Methods
double-blind, placebo-controlled trial, randomized, supplemented with 500 mg rutin or placebo per day for 3 months
Blinding
Double-blind
Duration
3 months
Funding
Unclear
This study aimed to investigate the effects of rutin flavonoid in type 2 diabetes mellitus (T2DM) patients. In this trial (double-blind, placebo-controlled), 50 T2DM patients (supplement, n = 25 and placebo, n = 25) were randomized and supplemented with 500 mg rutin or placebo per day for 3-months. At the beginning and at the end of the study, metabolic parameters including fasting blood glucose (FBG), insulin, glycosylated hemoglobin (HbA1c), homeostasis model assessment of insulin resistance (HOMO-IR), quantitative insulin sensitivity check index (QUICKI), homeostasis model assessment of β-cell function (HOMA-β), triglyceride (TG), total cholesterol (CHOL), high-density and low-density lipoprotein cholesterol (HDL-c and LDL-c), and atherogenic index of plasma (AIP), inflammatory and oxidative stress markers such as interleukin 6 (IL-6), total antioxidant capacity (TAC), and malondialdehyde (MDA) and brain-derived neurotrophic factor (BDNF) were assessed. The results showed a significant decrease in FBG, insulin, HbA1c, HOMO-IR, LDL-c, TG, VLDL, CHOL, LDL-c.HDL-c ratio, AIP, IL-6, and MDA and a significant increase in HDL-c, QUICKI index, BDNF, and TAC compared with the initial value (p for all <.05). In the adjusted model, the mean changes of FBG, insulin, HbA1c, HOMO-IR, LDL-c, CHOL, LDL.HDL ratio, AIP, MDA, and IL-6 were significantly lower and mean changes of QUICKI index, HDL-c, and TAC were significantly higher in the rutin group compared with the placebo group (adjusted p for all <.05). It seems that rutin may have beneficial effects on improving metabolic parameters, BDNF, and inflammatory and oxidative stress factors in T2DM patients.

Research Insights

  • Rutin→Improved Insulin Levels

    mean changes of ... insulin ... were significantly lower in the rutin group compared with the placebo group

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    500 mg/day
  • Rutin→Improved Insulin Sensitivity

    mean changes of QUICKI index ... were significantly higher in the rutin group compared with the placebo group

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    500 mg/day
  • Rutin→Increased Brain-derived Neurotrophic Factor Level

    a significant increase in ... BDNF ... compared with the initial value

    Effect
    Beneficial
    Effect size
    Small
    Dose
    500 mg/day
  • Rutin→Increased High-Density Lipoprotein Cholesterol

    mean changes of ... HDL-c ... were significantly higher in the rutin group compared with the placebo group

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    500 mg/day
  • Rutin→Increased Total Serum Antioxidant Capacity

    mean changes of ... TAC ... were significantly higher in the rutin group compared with the placebo group

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    500 mg/day
  • Rutin→Reduced Atherogenic Index

    mean changes of ... AIP ... were significantly lower in the rutin group compared with the placebo group

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    500 mg/day
  • Rutin→Reduced Blood Cholesterol

    mean changes of ... CHOL ... were significantly lower in the rutin group compared with the placebo group

    Effect
    Beneficial
    Effect size
    Large
    Dose
    500 mg/day
  • Rutin→Reduced Fasting Blood Glucose Levels

    mean changes of FBG ... were significantly lower in the rutin group compared with the placebo group

    Effect
    Beneficial
    Effect size
    Large
    Dose
    500 mg/day
  • Rutin→Reduced HOMA-IR

    mean changes of ... HOMO-IR [sic] ... were significantly lower in the rutin group compared with the placebo group

    Effect
    Beneficial
    Effect size
    Large
    Dose
    500 mg/day
  • Rutin→Reduced Hemoglobin A1c

    mean changes of ... HbA1c ... were significantly lower in the rutin group compared with the placebo group

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    500 mg/day
  • Rutin→Reduced Interleukin-6 Levels

    mean changes of ... IL-6 ... were significantly lower in the rutin group compared with the placebo group

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    500 mg/day
  • Rutin→Reduced LDL Cholesterol

    a significant decrease in ... VLDL ... compared with the initial value

    Effect
    Beneficial
    Effect size
    Small
    Dose
    500 mg/day
  • Rutin→Reduced LDL to HDL Ratio

    mean changes of ... LDL.HDL ratio ... were significantly lower in the rutin group compared with the placebo group

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    500 mg/day
  • Rutin→Reduced Malondialdehyde Level

    mean changes of ... MDA ... were significantly lower in the rutin group compared with the placebo group

    Effect
    Beneficial
    Effect size
    Large
    Dose
    500 mg/day
  • Rutin→Reduced Triglyceride Levels

    a significant decrease in ... TG ... compared with the initial value

    Effect
    Beneficial
    Effect size
    Large
    Dose
    500 mg/day
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