The Health Benefits of Probiotic Lactiplantibacillus plantarum: A Systematic Review and Meta-Analysis.

2024-05-31
Probiotics and antimicrobial proteins 17(5)
- Amal Aljohani
- Noha Rashwan
- Shruti Vasani
- Ahmed Alkhawashki
- Tong Tong Wu
- Xingyi Lu
- Daniel A Castillo
- Jin Xiao

PubMed: 38816672
DOI: 10.1007/s12602-024-10287-3

Study Design

Type: Meta-Analysis
Population: patients with specific medical conditions
Methods: systematic review and meta-analysis to evaluate the scientific evidence on the impact of Lactiplantibacillus plantarum probiotic consumption on human health; out of 11,831 records, 135 studies were assessed qualitatively, and 18 studies were included in the meta-analysis

Rigorous Journal

To ensure effective administration of probiotics in clinical practice, it is crucial to comprehend the specific strains and their association with human health. Therefore, we conducted a systematic review and meta-analysis to evaluate the scientific evidence on the impact of Lactiplantibacillus plantarum probiotic consumption on human health. Out of 11,831 records, 135 studies were assessed qualitatively, and 18 studies were included in the meta-analysis. This systematic review demonstrated that probiotic supplementation with L. plantarum, either alone or in combination, can significantly improve outcomes for patients with specific medical conditions. Meta-analysis revealed notable benefits in periodontal health, evidenced by reduced pocket depth and bleeding on probing (p < 0.001); in gastroenterological health, marked by significant reductions in abdominal pain (p < 0.001); and in infectious disease, through a reduction in C-reactive protein levels (p < 0.001). Cardiovascular benefits included lowered total cholesterol and low-density lipoprotein cholesterol in the L. plantarum intervention group (p < 0.05). Our study's clinical significance highlights the importance of considering probiotic strain and their application to specific diseases when planning future studies and clinical interventions, emphasizing the need for further research in this area.

Research Insights

Lactiplantibacillus plantarum→Reduced Abdominal Pain
in gastroenterological health, marked by significant reductions in abdominal pain (p < 0.001)
Effect
Beneficial
Effect size
Moderate
Lactiplantibacillus plantarum→Reduced Bleeding on Probing (BOP)
Meta-analysis revealed notable benefits in periodontal health, evidenced by reduced pocket depth and bleeding on probing (p < 0.001)
Effect
Beneficial
Effect size
Moderate
Lactiplantibacillus plantarum→Reduced Blood Cholesterol
Cardiovascular benefits included lowered total cholesterol and low-density lipoprotein cholesterol in the L. plantarum intervention group (p < 0.05)
Effect
Beneficial
Effect size
Small
Lactiplantibacillus plantarum→Reduced C-Reactive Protein Levels
in infectious disease, through a reduction in C-reactive protein levels (p < 0.001)
Effect
Beneficial
Effect size
Moderate
Lactiplantibacillus plantarum→Reduced Low-Density Lipoprotein Level
Cardiovascular benefits included lowered total cholesterol and low-density lipoprotein cholesterol in the L. plantarum intervention group (p < 0.05)
Effect
Beneficial
Effect size
Small
Lactiplantibacillus plantarum→Reduced Pocket Depth
Meta-analysis revealed notable benefits in periodontal health, evidenced by reduced pocket depth and bleeding on probing (p < 0.001)
Effect
Beneficial
Effect size
Moderate
Lactobacillus plantarum SD5209→Improved Blood Lipid Profile
Cardiovascular benefits included lowered total cholesterol and low-density lipoprotein cholesterol in the L. plantarum intervention group (p < 0.05).
Effect
Beneficial
Effect size
Small
Lactobacillus plantarum SD5209→Improved Periodontal Health
Meta-analysis revealed notable benefits in periodontal health, evidenced by reduced pocket depth and bleeding on probing (p < 0.001)
Effect
Beneficial
Effect size
Moderate
Lactobacillus plantarum SD5209→Reduced Abdominal Pain
in gastroenterological health, marked by significant reductions in abdominal pain (p < 0.001)
Effect
Beneficial
Effect size
Moderate
Lactobacillus plantarum SD5209→Reduced Inflammation
in infectious disease, through a reduction in C-reactive protein levels (p < 0.001)
Effect
Beneficial
Effect size
Small