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The impact of chia seeds on diabetes, blood pressure, lipid profile, and obesity indicators: Systematic review and meta-regression analysis of 14 randomized controlled trials.

  • 2024-12
  • Prostaglandins & other lipid mediators 175
    • Hawal Lateef Fateh
    • Dyari H Ahmed
    • Maryam Sharifi Najafabadi
    • Jalal Moludi

Study Design

Type
Meta-Analysis
Sample size
n = 835
Population
14 clinical trials involving 835 participants
Methods
systematic review and meta-analysis, thorough search of relevant studies up to April 2024
This comprehensive systematic review and meta-analysis sought to investigate the impact of chia seed supplementation on obesity indicators and metabolic factors. Through a thorough search of relevant studies up to April 2024, 14 clinical trials involving 835 participants were included in the analysis. The findings revealed a notable decrease in triglyceride levels across both higher and lower doses of chia seeds, with weighted mean differences (WMD) of -8.69 mg/dL and -13.11 mg/dL, respectively. Additionally, a statistically significant reduction in LDL-C levels was observed solely in the higher dosage group, showing a WMD of -4.77 mg/dL. Moreover, although the decrease in systolic blood pressure (-2.78 mmHg) compared to the control group was statistically significant, it was only observed with the higher dosage. These results suggest that chia supplementation may offer beneficial effects on dyslipidemia, hypertension, and body weight, potentially mitigating the risk of cardiovascular disease.

Research Insights

  • chia seed→Reduced Body Weight

    These results suggest that chia supplementation may offer beneficial effects on dyslipidemia, hypertension, and body weight

    Effect
    Beneficial
    Effect size
    Small
    Dose
    lower doses
  • chia seed→Reduced LDL Cholesterol

    a statistically significant reduction in LDL-C levels was observed solely in the higher dosage group

    Effect
    Neutral
    Effect size
    Small
    Dose
    lower doses
  • chia seed→Reduced Systolic Blood Pressure

    it was only observed with the higher dosage

    Effect
    Neutral
    Effect size
    Small
    Dose
    lower doses
  • chia seed→Reduced Triglyceride Levels

    The findings revealed a notable decrease in triglyceride levels across both higher and lower doses of chia seeds, with weighted mean differences (WMD) of -8.69 mg/dL and -13.11 mg/dL, respectively.

    Effect
    Beneficial
    Effect size
    Small
    Dose
    lower doses
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