The impact of L-branched-chain amino acids and L-leucine on malnutrition, sarcopenia, and other outcomes in patients with chronic liver disease.
- 2020-10-19
- Expert review of gastroenterology & hepatology 15(2)
- Ana Luiza Soares Dos Santos
- Lucilene Rezende Anastácio
- PubMed: 32993404
- DOI: 10.1080/17474124.2021.1829470
Study Design
- Type
- Review
- Population
- patients with chronic liver disease or patients with liver cirrhosis
Introduction
Metabolic and hormonal disorders resulting from chronic liver diseases culminate in increased proteolysis and decreased protein synthesis, which contributes to the development and progression of malnutrition and, consequently, sarcopenia. Nutritional management of sarcopenia in liver cirrhosis is a continuously evolving field and data on essential amino acid supplementation in chronic liver diseases is scarce.Areas covered
This review encompasses the current literature on oral amino acids supplementation in patients with chronic liver disease or patients with liver cirrhosis to try to elucidate the possible effects of L-branched-chain amino acids and isolated L-leucine as a therapeutic approach to malnutrition and sarcopenia.Expert commentary
To ensure an optimal nutritional status and to reduce sarcopenia, it is necessary to assess nutritional status in all patients with liver cirrhosis and to apply nutritional interventions accordingly. The supply of calories, proteins, and essential amino acids is necessary for the maintenance of muscle mass and function. Although supplementation of L-branched-chain amino acids plays an important role in liver disease, L-leucine has been described as the main amino acid involved in protein turnover, reducing proteolysis, and stimulating protein synthesis.Research Insights
data on essential amino acid supplementation in chronic liver diseases is scarce
- Effect
- Neutral
- Effect size
- Small
data on essential amino acid supplementation in chronic liver diseases is scarce
- Effect
- Neutral
- Effect size
- Small