The Multi-Faceted Role of Gut Microbiota in Alopecia Areata.
- 2025-06-04
- Biomedicines 13(6)
- Andrea Severino
- Serena Porcari
- Debora Rondinella
- Enrico Capuano
- Tommaso Rozera
- Francesco Kaitsas
- Antonio Gasbarrini
- Giovanni Cammarota
- Gianluca Ianiro
- PubMed: 40564097
- DOI: 10.3390/biomedicines13061379
Study Design
- Type
- Review
Alopecia areata (AA) is a complex autoimmune disorder with multifactorial pathogenesis. Recent research highlights the gut microbiota as a possible key player in AA pathogenesis through the gut-skin axis: gut dysbiosis may disrupt intestinal barrier integrity and immune tolerance by affecting T regulatory cells, potentially contributing to disease onset and progression. The purpose of this review is to analyze the current evidence on the correlation between gut microbiota and AA, dissecting both the pathogenetic role of its alterations in the onset and progression of disease and its potential role as a therapeutic target.