The potential of Streptococcus thermophiles (TCI633) in the anti‐aging
- 2021-09-29
- Journal of Cosmetic Dermatology 21(6)
- Cheng Liu
- Ya-Ping Tseng
- Leong‐Perng Chan
- C. Liang
- PubMed: 34587358
- DOI: 10.1111/jocd.14445
Abstract
Background: Streptococcus thermophilus (TCI633) is a probiotic that has been newly isolated from human breast milk, and it can produce hyaluronic acid (HA) when colonizing the gastrointestinal (GI) tract of rodents and humans. A recent study has the established that TCI633 can alleviate synovial tissue inflammation and has potential to mitigate the progression of osteoarthritis.
Objective: TCI633 has not been available for use in skincare and this preliminary clinical study will assess its improvement of the skin.
Methods: In this study, DNA protection, Hyaluronidase assay, cell viability, and collagen synthesis on human fibroblasts of TCI633 were assessed. Subjects were enrolled in this clinical study and randomly assigned to the TCI633 or placebo group. Each subject was informed to intake two tablets daily for 8 weeks. Each subject was required to undergo skin condition inspection at weeks 0, 4, and 8 and hematology tests to monitor HA, superoxide dismutase (SOD) and catalase levels, and kidney and liver function at weeks 0 and 8.
Results: The effects of TCI633 supplementation, including the promotion of skin cell proliferation, the increase of their collagen content, their protection against DNA damage, and the inhibition of hyaluronidase activities, are investigated. Subjects were recruited for an 8-week long clinical trial to confirm the efficacy of TCI633 in improving the serum biochemical HA, SOD and catalase levels, and anti-skin age markers.
Conclusions: This work provides an alternative approach to improving health, indicating the potential of TCI633 supplementation to delay the aging of skin and improve its condition.
Keywords: Streptococcus thermophiles; anti-aging; skin.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Streptococcus thermophilus | Improved Skin Condition | Beneficial | Moderate |
| Streptococcus thermophilus | Increased Collagen Content | Beneficial | Moderate |
| Streptococcus thermophilus | Reduced DNA Damage | Beneficial | Moderate |
| Streptococcus thermophilus | Reduced Hyaluronidase Activity | Beneficial | Moderate |
| Streptococcus thermophilus SEBiotic | Improved Skin Condition | Beneficial | Moderate |
| Streptococcus thermophilus SEBiotic | Increased Collagen Content | Beneficial | Moderate |
| Streptococcus thermophilus SEBiotic | Reduced DNA Damage | Beneficial | Moderate |
| Streptococcus thermophilus SEBiotic | Reduced Hyaluronidase Activity | Beneficial | Moderate |
| Streptococcus thermophilus SL-21 | Improved Skin Condition | Beneficial | Moderate |
| Streptococcus thermophilus SL-21 | Increased Collagen Content | Beneficial | Moderate |
| Streptococcus thermophilus SL-21 | Increased Hyaluronic Acid Production | Beneficial | Moderate |
| Streptococcus thermophilus SL-21 | Reduced DNA Damage | Beneficial | Moderate |
| Streptococcus thermophilus SL-21 | Reduced Hyaluronidase Activity | Beneficial | Moderate |
| Streptococcus thermophilus ST-21 | Delayed Skin Aging | Beneficial | Moderate |
| Streptococcus thermophilus ST-21 | Improved Serum Hyaluronan Levels | Beneficial | Moderate |
| Streptococcus thermophilus ST-21 | Improved Skin Condition | Beneficial | Moderate |
| Streptococcus thermophilus ST-21 | Increased Collagen Content | Beneficial | Moderate |
| Streptococcus thermophilus ST-21 | Reduced DNA Damage | Beneficial | Moderate |
| Streptococcus thermophilus ST-21 | Reduced Hyaluronidase Activity | Beneficial | Moderate |
| Streptococcus thermophilus ST1447 | Improved Skin Condition | Beneficial | Moderate |
| Streptococcus thermophilus TH-4 | Improved Skin Condition | Beneficial | Moderate |
| Streptococcus thermophilus TH-4 | Increased Collagen Synthesis | Beneficial | Moderate |
| Streptococcus thermophilus TH-4 | Reduced DNA Damage | Beneficial | Moderate |
| Streptococcus thermophilus TH-4 | Reduced Hyaluronidase Activity | Beneficial | Moderate |
| Streptococcus thermophilus UASt-09 | Improved Serum Biochemical Catalase Levels | Beneficial | Moderate |
| Streptococcus thermophilus UASt-09 | Improved Serum Biochemical HA Levels | Beneficial | Moderate |
| Streptococcus thermophilus UASt-09 | Improved Skin Cell Proliferation | Beneficial | Moderate |
| Streptococcus thermophilus UASt-09 | Increased Collagen Content | Beneficial | Moderate |
| Streptococcus thermophilus UASt-09 | Increased Serum Superoxide Dismutase Levels | Beneficial | Moderate |
| Streptococcus thermophilus UASt-09 | Reduced DNA Damage | Beneficial | Moderate |
| Streptococcus thermophilus UASt-09 | Reduced Hyaluronidase Activity | Beneficial | Moderate |
| Streptococcus thermophilus VPro 23 | Delayed Skin Aging | Beneficial | Moderate |
| Streptococcus thermophilus VPro 23 | Improved Skin Condition | Beneficial | Moderate |
| Streptococcus thermophilus VPro 23 | Increased Collagen Content | Beneficial | Moderate |
| Streptococcus thermophilus VPro 23 | Reduced DNA Damage | Beneficial | Moderate |
| Streptococcus thermophilus VPro 23 | Reduced Hyaluronidase Activity | Beneficial | Moderate |
| Streptococcus thermophilus Y08 | Improved Skin Condition | Beneficial | Moderate |
| Streptococcus thermophilus Y08 | Increased Collagen Content | Beneficial | Moderate |
| Streptococcus thermophilus Y08 | Reduced DNA Damage | Beneficial | Moderate |
| Streptococcus thermophilus Y08 | Reduced Hyaluronidase Activity | Beneficial | Moderate |
| Streptococcus thermophilus Y08 AF | Delayed Skin Aging | Beneficial | Moderate |
| Streptococcus thermophilus Y08 AF | Improved Serum Biochemical HA Levels | Beneficial | Moderate |
| Streptococcus thermophilus Y08 AF | Improved Skin Cell Proliferation | Beneficial | Moderate |
| Streptococcus thermophilus Y08 AF | Improved Skin Condition | Beneficial | Moderate |
| Streptococcus thermophilus Y08 AF | Increased Catalase Activity | Beneficial | Moderate |
| Streptococcus thermophilus Y08 AF | Increased Collagen Content | Beneficial | Moderate |
| Streptococcus thermophilus Y08 AF | Increased Superoxide Dismutase Levels | Beneficial | Moderate |
| Streptococcus thermophilus Y08 AF | Reduced DNA Damage | Beneficial | Moderate |
| Streptococcus thermophilus Y08 AF | Reduced Hyaluronidase Activity | Beneficial | Moderate |