- 2026-07-08
- International ophthalmology 46(1)
Study Design
- Type
- Meta-Analysis
- Sample size
- n = 486
- Population
- 486 individuals in the T2DM (n=258) and DR (n=228) groups
- Methods
- Meta-analysis of published studies; literature search up to October 2024 on PubMed, Embase, Web of Science; outcomes: diversity and gut microbiota composition; analysis in Review Manager (RevMan) Version 5.3
Purpose
The results of human observational studies on the correlation between gut microbiota and diabetic retinopathy (DR) are discrepant. This meta-analysis aimed to evaluate the specificity of the gut microbiota in DR patients compared to patients with type 2 diabetes mellitus (T2DM).Methods
All published literature up to October 2024 was searched by two researchers on PubMed, Embase and Web of Science databases. Diversity and gut microbiota composition were the main outcomes. The meta-analysis was conducted in Review Manager (RevMan) Version 5.3.Results
Eight studies, investigating gut microbiota by collecting stool samples, conducted in China and India were included in this meta-analysis, involving a total of 486 individuals in the T2DM (n = 258) and DR (n = 228) groups. No significant difference in alpha-diversity was observed between T2DM and DR patients. The pooled estimate showed that, at the phylum level, the abundances of Patescibacteria, and Synergistetes were significantly lower, and Verrucomicrobia were considerably higher in DR patients than in T2DM patients. At the genus level, DR patients had an increase in Bacteroides compared to T2DM.Conclusions
In this meta-analysis with a small number of studies and relatively high heterogeneity, changes in gut microbiota were associated with DR, commonly reflected by a reduction in beneficial species and an increase in pathogenic species influencing metabolic pathways.