- 2022-08-17
- Journal of health, population, and nutrition 41(1)
- Menul Ayu Umborowati
- Damayanti Damayanti
- Sylvia Anggraeni
- Anang Endaryanto
- Ingrid S Surono
- Isaak Effendy
- Cita Rosita Sigit Prakoeswa
Study Design
- Type
- Meta-Analysis
- Sample size
- n = 241
- Population
- adult patients with AD
- Methods
- All randomized controlled trials of probiotics for the treatment of adult AD published before December 2020 were included in this study from the PubMed databases and manual searching.
Background
Atopic dermatitis (AD) is chronic inflammatory skin disease that is relapsing and a serious condition that disrupts the quality of life of affected individuals. Probiotics are an immunomodulator that can enhance the immune control of atopic dermatitis.Methods
All randomized controlled trials of probiotics for the treatment of adult AD published before December 2020 were included in this study from the PubMed databases and manual searching.Results
Six randomized controlled trials (n = 241) were selected for this meta-analysis study. Probiotics were effective in treating adult patients with AD, indicated by the decrease in Scoring Atopic Dermatitis/SCORAD (Mean Difference (MD) - 7.90, 95% CI - 7.25 to - 6.92; p < 0.00001; I2 = 96%) and improved quality of life (MD - 7.68, 95% CI - 14.08 to - 1.29; p = 0.02; I2 = 47%) which were statistically significant. However, skin severity, itch severity, Dermatology Life Quality Index (DLQI), IL-4, TFN-γ, and IgE showed no significant difference in this meta-analysis study (p > 0.05).Limitations
The study found no available data for side effects of probiotics.Strength
This meta-analysis analyzed a total of 241 AD patients of Asian and European origin.Conclusion
The use of probiotics decreased SCORAD significantly in adult patients with AD. Probiotics can improve the quality of life of patients with AD. The use of probiotics in atopic dermatitis has been widely studied, with controversial results. This meta-analysis suggests that the use of probiotics can improve SCORAD and the quality of life of patients with atopic dermatitis.