The supplementation of L-carnitine in critically ill patients with sepsis: a systematic review and meta-analysis of randomized controlled trials.
- 2024-10-05
- European journal of medical research 29(1)
- Chang Meng
- Yudan Ma
- Ning Fu
- Jie Li
- Biao Sun
- Zhichao Li
- Qing Wang
- Peng Liu
- PubMed: 39367436
- DOI: 10.1186/s40001-024-02087-w
Study Design
- Type
- Meta-Analysis
- Sample size
- n = 356
- Population
- patients with sepsis
- Methods
- meta-analysis; search of PubMed, Embase, and Cochrane Library; risk ratio pooled with 95% CI; review per Cochrane Handbook and PRISMA; registered with INPLASY
Objectives
The evidence suggests that L-carnitine may reduce mortality in critically ill patients with sepsis. However, the conclusions of different studies are inconsistent. A meta-analysis was conducted to evaluate the effect of L-carnitine compliance on mortality in patients with sepsis.Methods
A search of the PubMed, Embase, and Cochrane Library databases was conducted on 1 June 2024. The risk ratio (RR) was pooled with a 95% confidence interval (CI) for dichotomous data. The publications were subjected to a review in accordance with the guidelines set forth in the Cochrane Handbook and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). This study has been registered with INPLASY (number INPLASY202460086).Results
A total of 356 patients were included in four randomized controlled trials. The results indicated that L-carnitine supplementation was not associated with 28-day mortality in sepsis patients (RR: 0.65; 95% CI 0.33-1.28; I2 = 70%; P = 0.21). And there was no significant effect on 12-month mortality (RR: 0.72; 95% CI 0.47-1.11; I2 = 0%; P = 0.14) compared to placebo.Conclusions
The use of L-carnitine was not found to be significantly correlated with 28-day or 12-month mortality in patients with sepsis.Research Insights
And there was no significant effect on 12-month mortality (RR: 0.72; 95% CI 0.47-1.11; I2 = 0%; P = 0.14).
- Effect
- Neutral
- Effect size
- Small