The triglyceride-lowering effect of supplementation with dual probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032: Reduction of fasting plasma lysophosphatidylcholines in nondiabetic and hypertriglyceridemic subjects.
- 2015-08
- Nutrition, Metabolism and Cardiovascular Diseases 25(8)
- H. Y. Ahn
- M. Kim
- Y. Ahn
- J. Sim
- Il-dong Choi
- S. Lee
- J. H. Lee
- PubMed: 26044516
- DOI: 10.1016/j.numecd.2015.05.002
Abstract
Background and aims: This study evaluated the triglyceride (TG)-lowering effects of consuming dual probiotic strains of Lactobacillus curvatus (L. curvatus) HY7601 and Lactobacillus plantarum (L. plantarum) KY1032 on the fasting plasma metabolome.
Methods and results: A randomized, double-blind, placebo-controlled study was conducted on 92 participants with hypertriglyceridemia but without diabetes. Over a 12-week testing period, the probiotic group consumed 2 g of powder containing 5 × 10(9) colony-forming units (cfu) of L. curvatus HY7601 and 5 × 10(9) cfu of L. plantarum KY1032 each day, whereas the placebo group consumed the same product without probiotics. Fasting plasma metabolomes were profiled using UPLC-LTQ-Orbitrap MS. After 12 weeks of treatment, the probiotic group displayed a 20% reduction (p = 0.001) in serum TGs and 25% increases (p=0.001) in apolipoprotein A-V (apoA-V). At the 12-week follow-up assessment, the following 11 plasma metabolites were significantly reduced in the probiotic group than the placebo group: palmitoleamide, palmitic amide, oleamide, and lysophosphatidyl choline (lysoPC) containing C14:0, C16:1, C16:0, C17:0, C18:3, C18:2, C18:1, and C20:3. In the probiotic group, changes (▵) in TG were negatively correlated with ▵ apoA-V, which was positively correlated with ▵ FFA. In addition, ▵ FFA was strongly and positively correlated with ▵ lysoPCs in the probiotic group but not the placebo group.
Conclusions: The triglyceride-lowering effects of probiotic supplementation, partly through elevated apoA-V, in borderline to moderate hypertriglyceridemic subjects showed reductions in plasma metabolites, fatty acid primary amides and lysoPCs (NCT02215694; http://www.clinicaltrials.gov). Clinical trials: NCT02215694; http://www.clinicaltrials.gov.
Keywords: Apolipoprotein A-V; Hypertriglyceridemic; Lysopcs; Probiotic; Triglyceride.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus curvatus | Increased Apolipoprotein A-V Levels | Beneficial | Large |
| Lactobacillus curvatus | Reduced Plasma Ammonia Levels | Beneficial | Moderate |
| Lactobacillus curvatus | Reduced Triglyceride Levels | Beneficial | Large |
| Lactobacillus plantarum R1012 | Increased Apolipoprotein A-V Levels | Beneficial | Large |
| Lactobacillus plantarum R1012 | Reduced Plasma Ammonia Levels | Beneficial | Moderate |
| Lactobacillus plantarum R1012 | Reduced Triglyceride Levels | Beneficial | Large |