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[Therapeutic effect of acupoint injection as adjuvant treatment on dry eyes of convalescent herpes simplex keratitis].

  • 2020-10-01
  • Zhongguo zhen jiu = Chinese acupuncture & moxibustion 40(10)
    • Guang-Hong Zhang
    • Xiao-Yu Li
    • Du-Jun Li
    • Ke-Hu Wu
    • Lin Wu
    • Ji-Hong Luo

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 60
Population
60 patients with dry eyes of convalescent herpes simplex keratitis
Methods
randomized into an observation group and a control group; control group received artificial tears and anti-inflammatory drugs; observation group additionally received acupoint injection of houttuynia cordata at Neiqiuhou, 3 mL each time, once a day for 3 injections then once every two days for 3 times; one course of 6 injections
Duration
one course (6 injections, over approximately 9–12 days) and follow-up at 7, 15, and 30 days after treatment

Objective

To evaluate the clinical effect of acupoint injection of houttuynia cordata as the accessory treatment on dry eyes of convalescent herpes simplex keratitis (HSK).

Methods

A total of 60 patients with dry eyes of convalescent HSK were randomized into an observation group and a control group, 30 cases in each one. In the control group, the artificial tears and anti-inflammatory drugs were combined in treatment. In the observation group, on the base of the treatment as the control group, the acupoint injection of houttuynia cordata at Neiqiuhou (Extra) was combined, 3 mL each time, once a day. After consecutive 3 injections, the injection was adjusted to be once every two days, consecutively for 3 times. The treatment for 6 times was as one course and one course of treatment was required. Separately, before treatment and in 7, 15 and 30 days after treatment, the changes of the scores of visual analogue scale (VAS), theresults of SchirmerⅠtest (SⅠT), the tear break-up time (BUT) and the score of corneal fluorescein staining (CFS) were observed and analyzed in the patients of the two groups.

Results

In 7, 15 and 30 days after treatment, VAS scores and CFS scores were all reduced as compared with those before treatment in the patients of the two groups (P<0.05), and the scores of VAS and CFS in the observation group were lower than those in the control group (P<0.05). In 7, 15 and 30 days after treatment, the values of SⅠT and BUT were all increased as compared with those before treatment in the patients of the two groups (P<0.05), and the values in the observation group were higher than the control group in 15 and 30 days after treatment (P<0.05).

Conclusion

Acupoint injection of houttuynia cordata promotes corneal epithelial recovery, reduces the discomfort symptoms as well as increases tear secretion and the stability of tear film in dry eyes of convalescent herpes simplex keratitis.

Research Insights

  • Houttuynia→Increased Schirmer Test Value

    In 7, 15 and 30 days after treatment, the values of SⅠT ... were all increased as compared with those before treatment in the patients of the two groups (P<0.05), and the values in the observation group were higher than the control group in 15 and 30 days after treatment (P<0.05).

    Effect
    Beneficial
    Effect size
    Small
    Dose
    3 mL per injection, once daily for 3 injections then once every two days for 3 injections (total 6 injections)
  • Houttuynia→Increased Tear Break-Up Time

    In 7, 15 and 30 days after treatment, the values of ... BUT were all increased as compared with those before treatment in the patients of the two groups (P<0.05), and the values in the observation group were higher than the control group in 15 and 30 days after treatment (P<0.05).

    Effect
    Beneficial
    Effect size
    Small
    Dose
    3 mL per injection, once daily for 3 injections then once every two days for 3 injections (total 6 injections)
  • Houttuynia→Reduced Corneal Fluorescein Staining Score

    In 7, 15 and 30 days after treatment, ... CFS scores were all reduced as compared with those before treatment in the patients of the two groups (P<0.05), and ... CFS in the observation group were lower than those in the control group (P<0.05).

    Effect
    Beneficial
    Effect size
    Small
    Dose
    3 mL per injection, once daily for 3 injections then once every two days for 3 injections (total 6 injections)
  • Houttuynia→Reduced Visceral Fat

    In 7, 15 and 30 days after treatment, VAS scores ... were all reduced as compared with those before treatment in the patients of the two groups (P<0.05), and the scores of VAS ... in the observation group were lower than those in the control group (P<0.05).

    Effect
    Beneficial
    Effect size
    Small
    Dose
    3 mL per injection, once daily for 3 injections then once every two days for 3 injections (total 6 injections)
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