Therapeutic effect of total glucosides of paeony on IgA vasculitis nephritis: progress and prospects.

2024-11-25
Molecular biology reports 52(1)
- Zhifeng Wang
- Jiao Yang
- Pengfen He
- Junfeng Lan
- Ting Shi
- Shuangfeng Xu
- Zhihui Hao
- Yujiang Xi
- Jian Wang
- Ping He

PubMed: 39585482
DOI: 10.1007/s11033-024-10041-6

Study Design

Type: Review

IgA vasculitis nephritis (IgAVN), a type of immune system disease characterized by the deposition of IgA in the mesangial area of the glomerulus, is most common in children. Corticosteroids and immunosuppressants agents are commonly prescribed for the clinical management of IgAVN; however, these therapies are associated with numerous adverse reactions. This necessitates the discovery of alternative, potential therapeutic agents that can offer a safer treatment option. Natural plants contain abundant total glucosides of paeony (TGP), which represent one of the most prevalent secondary metabolites found within these organisms. TGP has been proven to be a safe and desirable natural medicine, with the most central ingredient being polyphenolic. TGP, a naturally occurring and cost-effective compound, exerts its therapeutic influence on IgAVN via diverse pathways and targets, with minimal side effects. Its substantial clinical potential underscores the importance of delving deeper into its pharmacological mechanisms, which hold great promise for novel drug development. This review examines the multifaceted therapeutic mechanisms of TGP in IgAVN encompassing modulation of Wnt/β-catenin pathways and programmed cell death pathways, antioxidant and anti-inflammatory effects, and enhancement of vascular repair. Additionally, we provide an overview of recent advancements in enhancing the bioavailability of TGP and highlight crucial considerations that may inform future research endeavors.

Research Insights

Peony→Improved Renal Function
TGP, a naturally occurring and cost-effective compound, exerts its therapeutic influence on IgAVN via diverse pathways and targets, with minimal side effects.
Effect
Beneficial
Effect size
Small
Peony→Improved Vascular Repair
This review examines the multifaceted therapeutic mechanisms of TGP in IgAVN encompassing modulation of Wnt/β-catenin pathways and programmed cell death pathways, antioxidant and anti-inflammatory effects, and enhancement of vascular repair.
Effect
Beneficial
Effect size
Small
Peony→Reduced Inflammation
This review examines the multifaceted therapeutic mechanisms of TGP in IgAVN encompassing modulation of Wnt/β-catenin pathways and programmed cell death pathways, antioxidant and anti-inflammatory effects, and enhancement of vascular repair.
Effect
Beneficial
Effect size
Small
Peony→Reduced Oxidative Stress
This review examines the multifaceted therapeutic mechanisms of TGP in IgAVN encompassing modulation of Wnt/β-catenin pathways and programmed cell death pathways, antioxidant and anti-inflammatory effects, and enhancement of vascular repair.
Effect
Beneficial
Effect size
Small

Adverse Events Reported

Peony→Overall tolerability
TGP, a naturally occurring and cost-effective compound, exerts its therapeutic influence on IgAVN via diverse pathways and targets, with minimal side effects.
Finding
Reported