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Therapeutic Efficacy of Flavonoids in Allergies: A Systematic Review of Randomized Controlled Trials.

  • 2022-04-13
  • Journal of immunology research 2022
    • Poliana Guiomar de Almeida Brasiel
    • Fernanda Verdini Guimarães
    • Patrícia Machado Rodrigues
    • Dumith Chequer Bou-Habib
    • Vinicius de Frias Carvalho

Study Design

Type
Systematic Review
Sample size
n = 990
Population
990 participants with allergic diseases (allergic rhinitis, asthma, atopic dermatitis) aged 6 to 69 years
Methods
Systematic review of RCTs, searching MEDLINE/PubMed, Scopus, Web of Science, Embase from inception to September 2021

Objective

To assess the clinical efficacy of flavonoid supplements on allergic diseases.

Design

Systematic review. Data Sources. MEDLINE/PubMed, Scopus, Web of Science, and Embase databases were searched from inception to September 2021. Eligibility Criteria for Selecting Studies. Eligible study designs were randomized controlled trials that investigated the effect of flavonoids applied to allergic diseases.

Results

This review included 15 randomized controlled trials, including allergic rhinitis/cedar pollinosis (n = 10), asthma (n = 3), and atopic dermatitis (n = 2). A total of 990 participants aged 6 to 69 years were included in these studies. Globally, 12 studies (80%) revealed some benefits of flavonoids (isolate or combined with other compounds) in allergic patients, while three studies (20%) reported no statistically significant impact on symptom scores and/or lung function. No severe adverse events related to treatment were reported. According to the GRADE system, the outcomes evaluated were of low to moderate quality of evidence.

Conclusions

Overall, this review suggests that the administration of flavonoids may provide a viable strategy for mitigating allergic symptoms. Future trials with high methodological quality are needed to establish definitive conclusions. This trial is registered with PROSPERO registration no. CRD42021237403.

Research Insights

  • Red Grape→Improved Lung Function

    Globally, 12 studies (80%) revealed some benefits of flavonoids... while three studies (20%) reported no statistically significant impact on symptom scores and/or lung function.

    Effect
    Neutral
    Effect size
    Small
  • Red Grape→Reduced Allergic Symptom Score

    Globally, 12 studies (80%) revealed some benefits of flavonoids (isolate or combined with other compounds) in allergic patients, while three studies (20%) reported no statistically significant impact on symptom scores and/or lung function.

    Effect
    Beneficial
    Effect size
    Small

Adverse Events Reported

  • Red Grape→Overall tolerability

    No severe adverse events related to treatment were reported.

    Finding
    Reported
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