Skip to main content
Supplement Research and Comparison WebsiteBest Price Guarantee
Supplement Research and Comparison Website

Abstract

To screen Bacillus clausii UBBC07 as a putative probiotic strain and to examine the protective effect of probiotic-B. clausii UBBC07 spore on uremia on rats induced by acetaminophen. In vitro tests performed to screen potential probiotic strains were gastric and bile acid resistance and ability to reduce pathogen adhesion to surfaces. An in vivo study was performed on rats (n = 18) which were randomly divided into three groups: group I, control-receives normal food and water, groups II and III receive acetaminophen i.p. at the dose of 550 mg/kg/day for 10 days, groups III was treated with B. clausii UBBC07 at a dose of 1 × 109 CFU/day for 15 days. Urea, creatinine, malondialdehyde (MDA), and GSH levels and antioxidant enzymes like super oxide dismutase (SOD) and catalase activity were considered to analyze renal failure. Plasma urea and creatinine levels (p < 0.05) significantly increase and SOD, catalase, and GSH activity level significantly decrease in group II as compared with the control group. After treatment with probiotic, there was a significant increase in SOD and catalase (p < 0.05) and a significant decrease in serum urea, creatinine, and MDA (p < 0.05) in group III in response to group II. The results also revealed that probiotic was able to tolerate pH 3.0-9.0 and 0.3% bile salt. The present study suggests that B. clausii UBBC07 could be used as a novel alternative natural therapy for uremia, a major syndrome of CKD.

Keywords: Bacillus clausii; Nephrotoxicity; Probiotic; Uremia.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bacillus clausiiImproved Antioxidant ActivityBeneficial
Large
Bacillus clausiiReduced Hepatic Oxidative StressBeneficial
Large
Bacillus clausii MTCC 5980Improved Antioxidant ActivityBeneficial
Large
Bacillus clausii MTCC 5980Reduced Uremia IndicatorsBeneficial
Large
Bacillus clausii SNZ-1971Improved Antioxidant ActivityBeneficial
Large
Bacillus clausii SNZ-1971Reduced Hepatic Oxidative StressBeneficial
Large
Bacillus clausii SNZ-1971Reduced Uremia LevelsBeneficial
Large
Back to top