Thermophile-fermented feed modulates the gut microbiota related to lactate metabolism in pigs.
- 2024-09-27
- Journal of applied microbiology 135(10)
- Shota Yoshikawa
- Kaede Itaya
- Ryo Hoshina
- Yukihiro Tashiro
- Wataru Suda
- Yuichiro Cho
- Makiko Matsuura
- Chie Shindo
- Toshiyuki Ito
- Masahira Hattori
- Hirokuni Miyamoto
- Hiroaki Kodama
- PubMed: 39333026
- DOI: 10.1093/jambio/lxae254
Aims
Extracts of fermented feed obtained via fermentation of marine animal resources with thermophilic Bacillaceae bacteria increase the fecundity of livestock. The intestinal bacterial profiles in response to long-term administration of this extract to pigs were investigated.Methods and results
Half of a swine farm was supplied with potable water containing an extract of fermented feed for more than 2 years, whereas the other half was supplied with potable water without the extract. Feces from 6-month-old pigs rearing in these two areas were collected. 16S rRNA gene sequencing and isolation of lactic acid bacteria revealed an increase in the D/L-lactate-producing bacterium, Lactobacillus amylovorus, and a decrease in several members of Clostridiales following administration of fermented feed. A lactate-utilizing bacterium, Megasphaera elsdenii, was more abundant in the feces of pigs in the fermented feed group. All representative isolates of M. elsdenii showed rapid utilization of D-lactate relative to L-lactate, and butyrate and valerate were the main products.Conclusion
The probiotic effect of fermented feed is associated with the modulation of lactate metabolism in the digestive organs of pigs.Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus amylovorus | Increased Lactate-Utilizing Bacteria | Beneficial | Moderate |
| Lactobacillus amylovorus | Modulated Gut Microbiota | Beneficial | Moderate |