Three New Phenolic Compounds From the Twigs and Leaves of Casearia glomerata.
- 2025-12-03
- Chemistry & biodiversity 23(2)
- Na Li
- Zi-Qi Jin
- Jing-Jing Zhang
- Yun-Na Wang
- Chan Chen
- Xiao-Li Li
- Hong-Liang Li
- Wei-Lie Xiao
- PubMed: 41337667
- DOI: 10.1002/cbdv.202502888
Study Design
- Methods
- Phytochemical studies, isolation, structure elucidation by NMR, IR, MS, UV, cytotoxic activity evaluation
- Funding
- Unclear
Phytochemical studies of the twigs and leaves of Casearia glomerata yielded three previously undescribed phenolic compounds, including two phenylpropanoid derivatives, Casearata A (1) and Casearata B (2), one butyrolactone, Casearata C (3), as well as eleven known compounds 4-14. Their structures were elucidated by nuclear magnetic resonance, infrared, mass spectrometry, and ultraviolet spectroscopy. The absolute configurations of the new compounds were determined by a combination of linear correlation coefficients (R2), DP4+ probability analysis, and electronic circular dichroism calculations. The cytotoxic activity of compounds 1-4 and 6-14 was evaluated. Among these, compound 7 exhibited weak inhibitory effects against MDA-MB-231, HCT-116, HepG2, and A549 tumor cell lines, with IC50 values of 21.70-39.08 µM.