Triglyceride-Lowering Effects of Two Probiotics, Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601, in a Rat Model of High-Fat Diet-Induced Hypertriglyceridemia.
- 2016-03-28
- Journal of Microbiology and Biotechnology 26(3)
- Il-dong Choi
- Sung-Hwan Kim
- Ji-Woong Jeong
- Dong Eun Lee
- C. Huh
- S. Hong
- J. Sim
- Y. Ahn
- PubMed: 26699746
- DOI: 10.4014/jmb.1512.12018
Study Design
- Type
- Randomized Controlled Trial (RCT)
- Sample size
- n = 3
- Population
- Male SD Wistar rats
- Methods
- Controlled experimental study
- Animal Study
Abstract
The triglyceride-lowering effect of probiotics Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601 were investigated. Male SD Wistar rats were randomly divided into three groups and fed high-fat diet (HFD), HFD and probiotics (5 X 10(9) CFU/day of L. plantarum KY1032 and 5 X 10(9) CFU/day of L. curvatus HY7601), or normal diet for 6 weeks. Probiotic treatment significantly lowered the elevated plasma triglyceride and increased plasma free fatty acid, glycerol, and plasma apolipoprotein A-V (ApoA-V) levels. The probiotic-treated group showed elevated hepatic mRNA expression of PPARα, bile acid receptor (FXR), and ApoA-V. These results demonstrate that L. plantarum KY1032 and L. curvatus HY7601 lower triglycerides in hypertriglyceridemic rats by upregulating ApoA-V, PPARα, and FXR.
Keywords: Lactobacillus curvatus; Lactobacillus plantarum; Triglyceride; apolipoprotein A-V; probiotics.