Water-soluble gadolinium fullerenes Gd@C82-TEGs as a potential magnetic resonance imaging contrast agent.
- 2026-04-10
- PloS one 21(4)
- PubMed: 41961832
- DOI: 10.1371/journal.pone.0346592
Study Design
- Methods
- Fabrication of Gd@C82-TEGs nanoparticles, characterization of size, shape, relaxivity, and in vitro MRI and cytotoxicity testing.
- Funding
- Unclear
The water-soluble gadolinium fullerenes Gd@C82-TEGs nanoparticles as a novel magnetic resonance imaging (MRI) contrast agent were fabricated by the metal fullerenes Gd@C82 assembled with tetraethylene glycol (TEG). The loading Gd amount in Gd@C82-TEGs nanoparticles was 8.0 wt%. The average particle size of water-soluble Gd@C82-TEGs nanoparticles was 97 nm and the nanoparticles were uniformly spherical shape and had good dispersibility and no aggregation. The 97 nm spherical shape of Gd@C82-TEG nanoparticles ensured high relaxivity. The proton relaxivity (r1) and transverse relaxivity (r2) were high up to 37.1 mM-1·s-1 and 64.9 mM-1·s-1, which greater than that of commercial Magnevist under the same conditions. The Gd@C82-TEGs nanoparticles exhibited pronounced T1-weighted MRI in vitro. The MRI signal-enhancing efficiency of Gd@C82-TEGs nanoparticles was superior to that of gadolinium diethylenetriamine pentaacetate Gd-DTPA (Magnevist). The Gd@C82-TEGs nanoparticles had no significant effect on cell metabolism and structure, and the survival rate of cells was more than 80%, which indicated that the as-prepared Gd@C82-TEGs nanoparticles were no cytotoxicity.
Research Insights
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