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What is the effect of lactoferrin on oral and jawbone tissue repair? A systematic review.

  • 2024-01
  • The British journal of oral & maxillofacial surgery 62(1)
    • Camila Barcellos Calderipe
    • Alini Cardoso Soares
    • Rafael Dos Santos Giorgis
    • Antonio Cesar Manentti Fogaça
    • Marcos Antonio Torriani
    • Luisa Quevedo Grave
    • Lauren Frenzel Schuch
    • Ana Carolina Uchoa Vasconcelos

Study Design

Type
Systematic Review
Sample size
n = 742
Methods
literature search of PubMed/MEDLINE, Scopus, Embase, Web of Science, LILACS, and Cochrane databases according to PRISMA 2020
Currently, there is growing interest in the potential use of lactoferrin (LTF), a member of the transferrin family, for the improvement of tissue healing. In this sense, a literature search was conducted to integrate data published on the effect of LTF on jawbone repair. PubMed/MEDLINE, Scopus, Embase, Web of Science, LILACS, and Cochrane databases were retrieved according to the PRISMA 2020 statement. Articles in English, Spanish, and Portuguese were recovered, with no year restriction. In vitro, in vivo, and clinical studies were selected. A total of 742 articles were retrieved, 11 of which met the inclusion criteria (5 in vitro and 5 in vivo studies, and one clinical trial). The included data demonstrated wide variations in study design and LTF therapy protocols. Cell proliferation and viability were the primary outcomes evaluated in the in vitro studies, all of which reported a potential effect of LTF on the repair process. Of three in vivo studies, one reported a reduction in the overall healing rate, whereas the other two showed that LTF inhibited bone resorption and increased bone formation. The clinical trial's findings showed that LTF is a potential promoter of wound repair in patients with medication-related osteonecrosis of the jaws. Overall, data from the studies support a potential effect of LTF therapy on the process of jawbone repair.

Research Insights

  • Lactoferrin→Improved Wound Repair

    The clinical trial's findings showed that LTF is a potential promoter of wound repair in patients with medication-related osteonecrosis of the jaws.

    Effect
    Beneficial
    Effect size
    Small
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