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Whole genome sequence analysis of Bifidobacterium animalis subsp. lactis KL101 and comparative genomics with BB12.

  • 2026-03
  • Journal of animal science and technology 68(2)

Study Design

Population
B. animalis subsp. lactis KL101, isolated from infant feces
Methods
Whole genome sequence analysis and comparative genomic analysis of the KL101 strain in comparison to the BB12 strain
Bifidobacterium species is a prominent bacterium in the human gut, particularly in infants, where it plays an important role in maintaining gut health. The whole genome sequence of B. animalis subsp. lactis KL101 (KL101), isolated from infant feces, exhibits a compact structure with a genome size of approximately 1.92 Mbp comprising 1,555 coding sequences. Key chromosomal characteristics are genes encoding bile salt hydrolase and the thioredoxin system, which contribute to bile acid resistance and the oxidative stress response, respectively. Moreover, the genome has a significant number of genes that play a role in carbohydrate metabolism, supporting its probiotic functions. The comparative genomic analysis of the KL101 strain, in comparison to the well-known BB12 strain (B. animalis subsp. lactis BB12), reveals unique and similar characteristics. Although both strains have a similar guanine-cytosine (GC) content, KL101 exhibits unique genomic characteristics that may contribute to its specific adaptations in the infant gut. The results demonstrate that KL101 is highly adapted, with a genome specifically designed to efficiently process carbohydrates, withstand stress, and interact with its host. These findings enhance our understanding of KL101, supporting its potential applications in dietary supplements and health foods aimed at improving gut health.

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