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Yacon syrup reduces postprandial glycemic response to breakfast: A randomized, crossover, double-blind clinical trial.

  • 2019-09-15
  • Food research international (Ottawa, Ont.) 126
    • Lia Silveira Adriano
    • Ana Paula Dionísio
    • Fernando Antônio Pinto de Abreu
    • Antônio Augusto Ferreira Carioca
    • Guilherme Julião Zocolo
    • Nedio Jair Wurlitzer
    • Claudia de Oliveira Pinto
    • Ariclécio Cunha de Oliveira
    • Helena Alves de Carvalho Sampaio

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 40
Population
40 women (20 normal weight and 20 grade I obese)
Methods
randomized, crossover, double-blind clinical intervention; two-arms with at least a one-week wash-out; breakfast +40 g of placebo or 40 g of yacon syrup (14 g of FOS); blood samples at 15, 30, 45, 60, 90, 120 min
Blinding
Double-blind
Yacon is a root rich in fructooligosaccharides (FOS), which act as prebiotics. Numerous studies have shown promising results in the technological aspects of producing yacon syrup. However, uncertainties exist concerning whether yacon syrup can modulate postprandial glucose and lipid profiles. In order to assess the effect of yacon syrup on postprandial glucose, insulin and triglyceride (TG) responses, a randomized, crossover, double-blind clinical intervention with 40 women (20 normal weight and 20 grade I obese) was performed. Participants underwent two-arms of intervention with at least a one-week wash-out period between visits. On each intervention day, after 12 h of fasting, an aliquot of blood was collected. For intervention A, volunteers consumed breakfast +40 g of placebo, whereas for intervention B, participants consumed breakfast +40 g of yacon syrup (14 g of FOS). Blood samples were drawn at 15, 30, 45, 60, 90, and 120 min. Glucose and insulin concentrations were lowered after yacon syrup intake as compared to placebo at following times: 30 min for glucose and 15, 30 and 45 min for insulin. In conclusion, yacon syrup has a postprandial decreasing effect glucose and insulin concentrations in adult women. This effect was not evident for triglyceride concentration. Clinical trial registry: RBR-33wf46. Available in: http://www.ensaiosclinicos.gov.br/rg/RBR-33wf46/.

Research Insights

  • Yacon→Reduced Postprandial Glucose

    Glucose and insulin concentrations were lowered after yacon syrup intake as compared to placebo at following times: 30 min for glucose

    Effect
    Beneficial
    Effect size
    Small
    Dose
    40 g of yacon syrup (14 g of FOS)
  • Yacon→Reduced Postprandial Insulin

    Glucose and insulin concentrations were lowered after yacon syrup intake as compared to placebo at following times: 15, 30 and 45 min for insulin

    Effect
    Beneficial
    Effect size
    Small
    Dose
    40 g of yacon syrup (14 g of FOS)
  • Yacon→Reduced Postprandial Triglyceride Level

    This effect was not evident for triglyceride concentration.

    Effect
    Neutral
    Effect size
    Small
    Dose
    40 g of yacon syrup (14 g of FOS)
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