Vitamin A and Improved Retinal Nerve Fiber Layer Thickness

• Vitamin supplementation in the treatment of optic neuritis: A systematic review and meta-analysis.

  • 2025-12
  • Meta-Analysis · n = 2,465
  • Multiple sclerosis and related disorders 104
  • • Patrick J Gaffney
    • Rajesh K Gupta

  • PubMed: 41124782
  • DOI: 10.1016/j.msard.2025.106797

  4 Insights on

  • Improved Retinal Nerve Fiber Layer Thickness

  • High evidence
  • Clinical

  Significant improvements in RNFL thickness due to vitamin A, visual acuity due to vitamins B1, B6, and B12, foveal sensitivity due to vitamins B1, B6, and B12, and the rate of conversion of ON to MS due to vitamin D were observed in individual studies.

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes