Vitamin B1 and Reduced Lactate Levels

• Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials.

  • 2024-11
  • Meta-Analysis · n = 3,494
  • Clinical nutrition (Edinburgh, Scotland) 43(11)
  • • Nobuto Nakanishi
    • Yoshinobu Abe
    • Mizue Matsuo
    • Akihito Tampo
    • Kohei Yamada
    • Junji Hatakeyama
    • Minoru Yoshida
    • Ryo Yamamoto
    • Naoki Higashibeppu
    • Kensuke Nakamura
    • Joji Kotani

  • PubMed: 39307094
  • DOI: 10.1016/j.clnu.2024.09.002

  5 Insights on

  • Reduced Lactate Levels

  • High evidence
  • Clinical

  thiamine administration may reduce ... lactate level (MD, -0.34 mmol/L; 95% CI, -0.63 to -0.05 mmol/L; Low CoE)

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

• Baseline measurements of cellular respiration affect the response to thiamine treatment in post-arrest patients.

  • 2026-08
  • RCT
  • Resuscitation 225
  • • Jacob Vine
    • John H Lee
    • Michael D Simpson
    • Anne V Grossestreuer
    • Karim Sorour
    • Muhammad M Zubair
    • Ari Moskowitz
    • Katherine M Berg
    • Xiaowen Liu
    • Michael W Donnino

  • PubMed: 41759812
  • DOI: 10.1016/j.resuscitation.2026.111029

  1 Insight on

  • Reduced Lactate Levels

  • High evidence
  • Clinical

  among patients with maximal or spare respiration above the median, thiamine treatment was associated with significantly lower lactate levels at 24 h (GMR = 0.61; 95% CI 0.44-0.83; p = 0.003 and GMR = 0.53; 95% CI 0.38-0.75; p < 0.001, respectively).

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes