Vitamin B1 and Reduced Mortality Risk

• Beyond Fluid Therapy: The Role of Vitamin C, Steroids, and Thiamine in Sepsis Management.

  • 2025-05-23
  • Review
  • Cureus 17(5)
  • • Courage O Idahor
    • Olamide Ogunfuwa
    • Ndidiamaka Ogbonna
    • Augustina Adigwe
    • Omo A Ogbeide

  • PubMed: 40546532
  • DOI: 10.7759/cureus.84666

  6 Insights on

  • Reduced Mortality Risk

  • Low evidence

  Combination therapy with hydrocortisone, vitamin C, and thiamine (the HAT protocol) has been associated with reduced vasopressor duration but has not consistently improved survival or other major clinical endpoints, despite its apparent safety.

  Effect

  Neutral

  Effect size

  Small

  Significant

  No