Skip to main content

Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin B1 and Reduced Thiamin Pyrophosphate Effect

Doses used in studies

mg/day: 50 (median 50, IQR 50–50) — 1 study

Time to effect

Median: 4 weeks · IQR 4 weeks–4 weeks · Range 4 weeks–4 weeks — Reported in 1 of 1 study

1 of 1 paper

Impact of thiamin supplementation on thiamin pyrophosphate effect and cardiac function in pediatric heart disease patients on diuretics: a randomized controlled trial.
- 2026-03-23
- RCT · n = 45
- Scientific reports 16(1)
- - Rathaporn Sumboonnanonda
  - Chodchanok Vijarnsorn
  - Puthita Saengpanit
  - Chatchawan Srisawat
  - Kwanjai Chotipanang
  - Sarawut Junnu
  - Supawan Kunnangja
  - Hathaichanok Rukprayoon
  - Phakkanan Phuangphan
  - Bordeesuda Suiwongsa
  - Sompong Liammongkolkul
  - Phakwan Laohathai
  - Narumon Densupsoontorn
- PubMed: 41872295
- DOI: 10.1038/s41598-026-45100-4
2 Insights on
- Reduced Thiamin Pyrophosphate Effect
- High evidence
- Rigorous Journal
- Clinical
After 4 weeks, no significant differences in changes in TPPE values (p = 0.540) ... were observed among the three groups.
Effect
Neutral
Effect size
Small
Significant
No
Dose
50 mg/day