Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis.
- 2021-11-09
- Systematic Review · n = 257
- Intensive care medicine 48(1)
- Tomoko Fujii
- Georgia Salanti
- Alessandro Belletti
- Rinaldo Bellomo
- Anitra Carr
- Toshi A Furukawa
- Nora Luethi
- Yan Luo
- Alessandro Putzu
- Chiara Sartini
- Yasushi Tsujimoto
- Andrew A Udy
- Fumitaka Yanase
- Paul J Young
- PubMed: 34750650
- DOI: 10.1007/s00134-021-06558-0
- High evidence
- Clinical
Adding glucocorticoid to other treatments shortened duration of vasopressor therapy (incremental mean difference, - 29.8 h [95% CI - 44.1 to - 15.5]) and ICU stay (incremental mean difference, - 1.3 days [95% CI - 2.2 to - 0.3]). [The effect of vitamin B1 alone on this outcome was not significant in the network meta-analysis; all comparisons not involving glucocorticoid showed no significant benefit.]
- Effect
- Neutral
- Effect size
- Small
- Significant
- No
- Dose
- very-high-dose (≥ 12 g/day), high-dose (< 12, ≥ 6 g/day), or low-dose (< 6 g/day)