Vitamin B1 and Reduced Vasopressor Duration

• Monotherapy or combinations? Intravenous vitamin C in sepsis and septic shock: An umbrella review of 31 systematic reviews.

  • 2026-07-01
  • Systematic Review
  • PloS one 21(7)
  • • Víctor Juan Vera-Ponce
    • Jhosmer Ballena-Caicedo
    • Lupita Ana Maria Valladolid-Sandoval
    • Fiorella E Zuzunaga-Montoya
    • Renzo Acosta-Porzoliz
    • Oriana Rivera-Lozada
    • Mario J Valladares-Garrido

  • PubMed: 42384633
  • DOI: 10.1371/journal.pone.0351072

  3 Insights on

  • Reduced Vasopressor Duration

  • High evidence
  • Clinical

  hemodynamic improvements (small decreases in ΔSOFA and vasopressor hours) were modest, did not translate into survival benefits, and were primarily attributable to the corticosteroid.

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  Not specified

• Beyond Fluid Therapy: The Role of Vitamin C, Steroids, and Thiamine in Sepsis Management.

  • 2025-05-23
  • Review
  • Cureus 17(5)
  • • Courage O Idahor
    • Olamide Ogunfuwa
    • Ndidiamaka Ogbonna
    • Augustina Adigwe
    • Omo A Ogbeide

  • PubMed: 40546532
  • DOI: 10.7759/cureus.84666

  6 Insights on

  • Reduced Vasopressor Duration

  • Low evidence

  Combination therapy with hydrocortisone, vitamin C, and thiamine (the HAT protocol) has been associated with reduced vasopressor duration but has not consistently improved survival or other major clinical endpoints, despite its apparent safety.

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes