Vitamin B1 and Reduced Vasopressor Requirement

Safety in these studies

Overall tolerabilityReported
Combination therapy with hydrocortisone, vitamin C, and thiamine (the HAT protocol) has been associated with reduced vasopressor duration but has not consistently improved survival or other major clinical endpoints, despite its apparent safety.
from: Beyond Fluid Therapy: The Role of Vitamin C, Steroids, and Thiamine in Sepsis Management.

1 of 1 paper

Beyond Fluid Therapy: The Role of Vitamin C, Steroids, and Thiamine in Sepsis Management.

2025-05-23
Review
Cureus 17(5)
- Courage O Idahor
- Olamide Ogunfuwa
- Ndidiamaka Ogbonna
- Augustina Adigwe
- Omo A Ogbeide

PubMed: 40546532
DOI: 10.7759/cureus.84666

6 Insights on

Reduced Vasopressor Requirement

Low evidence

Thiamine has demonstrated possible renal protective effects and improved lactate clearance, although its impact on mortality and vasopressor needs remains inconclusive.

Effect: Neutral
Effect size: Small
Significant: No