Vitamin B12 and Improved Attention Span

• The dihydrofolate reductase 19-bp deletion modifies the beneficial effect of B-vitamin therapy in mild cognitive impairment: pooled study of two randomized placebo-controlled trials.

  • 2021-11-12
  • RCT
  • Human molecular genetics 31(7)
  • • Yuanyuan Wu
    • A David Smith
    • Nasser E Bastani
    • Helga Refsum
    • Timothy Kwok

  • PubMed: 34788822
  • DOI: 10.1093/hmg/ddab246

  5 Insights on

  • Improved Attention Span

  • High evidence
  • Clinical

  significant benefits being observed only in those with ins/ins genotype (Beta = 0.315, P = 0.012)

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

  Dose

  not specified in abstract

• Neurological Implications of Vitamin B12 Deficiency in Diet: A Systematic Review and Meta-Analysis.

  • 2023-03-27
  • Review
  • Healthcare (Basel, Switzerland) 11(7)
  • • Mubarak Alruwaili
    • Rehana Basri
    • Raed AlRuwaili
    • Anas Mohammad Albarrak
    • Naif H Ali

  • PubMed: 37046885
  • DOI: 10.3390/healthcare11070958

  3 Insights on

  • Improved Attention Span

  • Low evidence
  • Mixed

  Vitamin B12's role in the improvement of neurological functions over a long-term period remains somewhat inconclusive to date, as the majority of our selected control trials did not display much correlation between the two factors

  Effect

  Neutral

  Effect size

  Small

  Significant

  No