Vitamin B12 and Improved Cognition

Doses used in studies

Time to effect

Median: 4 weeks · IQR 4 weeks–4 weeks · Range 4 weeks–4 weeks — Reported in 1 of 2 studies

Safety in these studies

Overall tolerabilityReported
B12 supplementation is generally well tolerated.
from: Vitamin B12 Supplementation: Is More Always Better?
acneiformReported
There are rare reports of acneiform and hypersensitivity responses, although these cannot be completely distinguished from reactions to, e.g., excipients.
from: Vitamin B12 Supplementation: Is More Always Better?
hypersensitivityReported
There are rare reports of acneiform and hypersensitivity responses, although these cannot be completely distinguished from reactions to, e.g., excipients.
from: Vitamin B12 Supplementation: Is More Always Better?
malignancyReported
Observational studies associate B12 supplementation and higher circulating B12 levels with increased risks of malignancy. However, these findings are inconsistent, and current evidence is insufficient to establish causality, as potential reverse causation remains a major concern.
from: Vitamin B12 Supplementation: Is More Always Better?

2 of 2 papersPopulation:

Vitamin B12 Supplementation: Is More Always Better?