Vitamin B12 and Improved Cognitive Function

• Vitamin B12 supplementation for growth, development, and cognition in children.

  • 2026-06-02
  • Meta-Analysis · n = 4,083
  • The Cochrane database of systematic reviews 2026(6)
  • • Doreen Y Larvie
    • Cristina E Güitrón Leal
    • Sudha Venkatramanan
    • Ximena E Palma Molina
    • Lili B Steel
    • Rebecca Kuriyan
    • Julia L Finkelstein

  • PubMed: 42227307
  • DOI: 10.1002/14651858.cd015264.pub2

  6 Insights on

  • Improved Cognitive Function

  • High evidence
  • Children

  There may be little to no difference between groups in cognitive function (e.g. attention) (standardised mean difference (SMD) 0.09, 95% CI -0.10 to 0.28; 2 trials, 438 children, low-certainty evidence)

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  0.9 µg/day to 150 µg/day

• Folate and vitamin B12 supplementation in patients with schizophrenia and low serum folate level: A 24-week randomized, double-blind, placebo-controlled study.

  • 2026-01
  • RCT · n = 36
  • Journal of the Formosan Medical Association = Taiwan yi zhi 125(1)
  • • Chun-Hsin Chen
    • Chih-Chiang Chiu
    • Yi-Hang Chiu
    • Chin-Hao Chang
    • Yu-Han Chang
    • Ming-Chyi Huang
    • Mong-Liang Lu
    • Po-Yu Chen

  • PubMed: 39645464
  • DOI: 10.1016/j.jfma.2024.11.019

  2 Insights on

  • Improved Cognitive Function

  • High evidence
  • Clinical

  There were no significant changes in scores of total and each subscale of PANSS, and Cogstate between the folate and placebo groups.

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  500 μg/day