Maternal supplementation of vitamin B12 in predominantly vegetarian pregnant women improves their vitamin B12 status and the neurodevelopment of their infants: the MATCOBIND multicentric double-blind randomised control trial.
- 2026-03
- RCT · n = 276
- BMJ paediatrics open 10(1)
- Jitender Nagpal
- Manu Mathur
- Swapnil Rawat
- Atul Singhal
- Rajendra Pant
- Anita Shah
- Laura Nixon
- Vijay Kumar Mishra
- Deepti Nagrath
- Michelle Heys
- Mario Cortina-Borja
- Colin Michie
- Jageshwor Gautam
- Shailendra Bir Karmacharya
- Snighda Rai
- Monica Lakhanpaul
- PubMed: 41850742
- DOI: 10.1136/bmjpo-2025-004112
- High evidence
- Large Human Trial
- Pregnant Women
Mental developmental quotients (DQs) were higher in the infants of group A: 103.7 (7.7) than group B: 101.7 (8.8); p=0.008). This corresponds to a mean difference of 7.8 centiles (p=0.007).
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes
- Dose
- 250 µg/day