Vitamin B12 and Increased Clinical Pregnancy Rate

• Does vitamin B12 influence clinical pregnancy outcome in the follicular-phase GnRH agonist protocol?

  • 2025-10-21
  • Observational
  • BMC pregnancy and childbirth 25(1)
  • • Xiaoning Wang
    • Kui Fu
    • Ying Zhang
    • Shengfang Jiang
    • Changjun Zhang

  • PubMed: 41120970
  • DOI: 10.1186/s12884-025-08250-3

  1 Insight on

  • Increased Clinical Pregnancy Rate

  • Low evidence
  • Clinical

  when the vitamin B12 value was ≤358.7 pg/ml, for every 10 pg/ml increase in the vitamin B12 value, the clinical pregnancy rate increased by 4% (OR=1.04, 95% CI=1.00, 1.08, P=0.03).

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes