Comparison of Efficacy and Safety of Parenteral vs Oral Route of Vitamin B12 Supplementation for the Treatment of Vitamin B12 Deficiency Anemia in Children: A Systematic Review.
- 2025-02-18
- Systematic Review
- Nutrition reviews 83(9)
- Meenakshi Sachdeva
- Abhishek Purohit
- Meenakshi Malik
- Lovely Jain
- Pranita Pradhan
- Joseph L Mathew
- PubMed: 39964959
- DOI: 10.1093/nutrit/nuae227
- High evidence
- Clinical
After 3 months, the parenteral route resulted in higher B12 levels compared with the oral route (median [IQR]: 653 [459, 835] vs 506 [399, 726] pg/mL). The changes from baseline in vitamin B12 levels (median [IQR]: 600 [389, 775] vs 399 [313, 606] pg/mL, P = .016) were also significantly greater with the parenteral route.
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes
- Dose
- 1000 µg initially parenterally followed by parenteral or oral therapy (dose not specified for maintenance)