Vitamin B12 and Reduced Anemia

• Vitamin B12 supplementation for growth, development, and cognition in children.

  • 2026-06-02
  • Meta-Analysis · n = 4,083
  • The Cochrane database of systematic reviews 2026(6)
  • • Doreen Y Larvie
    • Cristina E Güitrón Leal
    • Sudha Venkatramanan
    • Ximena E Palma Molina
    • Lili B Steel
    • Rebecca Kuriyan
    • Julia L Finkelstein

  • PubMed: 42227307
  • DOI: 10.1002/14651858.cd015264.pub2

  6 Insights on

  • Reduced Anemia

  • High evidence
  • Children

  There may be little to no difference between groups in anaemia (ARD 21 more per 1000, 95% CI 26 fewer to 191 more; 9.1% versus 4.5%; RR 1.48, 95% CI 0.41 to 5.27; 2 trials, 144 children; low-certainty evidence)

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  0.9 µg/day to 150 µg/day