Vitamin B12 and Reduced Anxiety

• High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression.

  • 2022-07-19
  • RCT · n = 307
  • Human psychopharmacology 37(6)
  • • David T Field
    • Rebekah O Cracknell
    • Jessica R Eastwood
    • Peter Scarfe
    • Claire M Williams
    • Ying Zheng
    • Teresa Tavassoli

  • PubMed: 35851507
  • DOI: 10.1002/hup.2852

  5 Insights on

  • Reduced Anxiety

  • High evidence
  • Large Human Trial
  • Adults

  Vitamin B12 supplementation produced trends towards changes in anxiety

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  high-dose

• Association of serum homocysteine, folate, and vitamin B12 and mood following the Swank and Wahls elimination dietary interventions in relapsing-remitting multiple sclerosis: Secondary analysis of the WAVES trial.

  • 2023-05-01
  • RCT · n = 77
  • Multiple sclerosis and related disorders 75
  • • Farnoosh Shemirani
    • Tyler J Titcomb
    • Solange M Saxby
    • Patrick Ten Eyck
    • Linda M Rubenstein
    • Karin F Hoth
    • Linda G Snetselaar
    • Terry L Wahls

  • PubMed: 37148578
  • DOI: 10.1016/j.msard.2023.104743

  3 Insights on

  • Reduced Anxiety

  • High evidence
  • Clinical

  Changes in serum levels of homocysteine and vitamin B12 were not associated with and did not mediate changes in HADS depression, anxiety, MHI total and four subscales scores (p > 0.05).

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  not specified (part of supplement regimen)